Prebiotic effect of fruit and vegetable shots containing Jerusalem artichoke inulin: a human intervention study - PubMed (original) (raw)
Randomized Controlled Trial
. 2010 Jul;104(2):233-40.
doi: 10.1017/S000711451000036X. Epub 2010 Mar 1.
Affiliations
- PMID: 20187995
- DOI: 10.1017/S000711451000036X
Randomized Controlled Trial
Prebiotic effect of fruit and vegetable shots containing Jerusalem artichoke inulin: a human intervention study
P Ramnani et al. Br J Nutr. 2010 Jul.
Abstract
The present study aimed to determine the prebiotic effect of fruit and vegetable shots containing inulin derived from Jerusalem artichoke (JA). A three-arm parallel, placebo-controlled, double-blind study was carried out with sixty-six healthy human volunteers (thirty-three men and thirty-three women, age range: 18-50 years). Subjects were randomised into three groups (n 22) assigned to consume either the test shots, pear-carrot-sea buckthorn (PCS) or plum-pear-beetroot (PPB), containing JA inulin (5 g/d) or the placebo. Fluorescent in situ hybridisation was used to monitor populations of total bacteria, bacteroides, bifidobacteria, Clostridium perfringens/histolyticum subgroup, Eubacterium rectale/Clostridium coccoides group, Lactobacillus/Enterococcus spp., Atopobium spp., Faecalibacterium prausnitzii and propionibacteria. Bifidobacteria levels were significantly higher on consumption of both the PCS and PPB shots (10.0 (sd 0.24) and 9.8 (sd 0.22) log10 cells/g faeces, respectively) compared with placebo (9.3 (sd 0.42) log10 cells/g faeces) (P < 0.0001). A small though significant increase in Lactobacillus/Enterococcus group was also observed for both the PCS and PPB shots (8.3 (sd 0.49) and 8.3 (sd 0.36) log10 cells/g faeces, respectively) compared with placebo (8.1 (sd 0.37) log10 cells/g faeces) (P = 0.042). Other bacterial groups and faecal SCFA concentrations remained unaffected. No extremities were seen in the adverse events, medication or bowel habits. A slight significant increase in flatulence was reported in the subjects consuming the PCS and PPB shots compared with placebo, but overall flatulence levels remained mild. A very high level of compliance (>90 %) to the product was observed. The present study confirms the prebiotic efficacy of fruit and vegetable shots containing JA inulin.
Similar articles
- A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a very-long-chain inulin extracted from globe artichoke (Cynara scolymus) in healthy human subjects.
Costabile A, Kolida S, Klinder A, Gietl E, Bäuerlein M, Frohberg C, Landschütze V, Gibson GR. Costabile A, et al. Br J Nutr. 2010 Oct;104(7):1007-17. doi: 10.1017/S0007114510001571. Epub 2010 Jul 1. Br J Nutr. 2010. PMID: 20591206 Clinical Trial. - A double-blind placebo-controlled study to establish the bifidogenic dose of inulin in healthy humans.
Kolida S, Meyer D, Gibson GR. Kolida S, et al. Eur J Clin Nutr. 2007 Oct;61(10):1189-95. doi: 10.1038/sj.ejcn.1602636. Epub 2007 Jan 31. Eur J Clin Nutr. 2007. PMID: 17268410 Clinical Trial. - Determination of the in vivo prebiotic potential of a maize-based whole grain breakfast cereal: a human feeding study.
Carvalho-Wells AL, Helmolz K, Nodet C, Molzer C, Leonard C, McKevith B, Thielecke F, Jackson KG, Tuohy KM. Carvalho-Wells AL, et al. Br J Nutr. 2010 Nov;104(9):1353-6. doi: 10.1017/S0007114510002084. Epub 2010 May 21. Br J Nutr. 2010. PMID: 20487589 Clinical Trial. - Food-based strategies to modulate the composition of the intestinal microbiota and their associated health effects.
Bosscher D, Breynaert A, Pieters L, Hermans N. Bosscher D, et al. J Physiol Pharmacol. 2009 Dec;60 Suppl 6:5-11. J Physiol Pharmacol. 2009. PMID: 20224145 Review.
Cited by
- Health Effects and Mechanisms of Inulin Action in Human Metabolism.
Alonso-Allende J, Milagro FI, Aranaz P. Alonso-Allende J, et al. Nutrients. 2024 Sep 2;16(17):2935. doi: 10.3390/nu16172935. Nutrients. 2024. PMID: 39275251 Free PMC article. Review. - Insights into the Mechanisms of Action of Akkermansia muciniphila in the Treatment of Non-Communicable Diseases.
Mruk-Mazurkiewicz H, Kulaszyńska M, Czarnecka W, Podkówka A, Ekstedt N, Zawodny P, Wierzbicka-Woś A, Marlicz W, Skupin B, Stachowska E, Łoniewski I, Skonieczna-Żydecka K. Mruk-Mazurkiewicz H, et al. Nutrients. 2024 May 29;16(11):1695. doi: 10.3390/nu16111695. Nutrients. 2024. PMID: 38892628 Free PMC article. Review. - Relationships between Habitual Polyphenol Consumption and Gut Microbiota in the INCLD Health Cohort.
Vita AA, Roberts KM, Gundersen A, Farris Y, Zwickey H, Bradley R, Weir TL. Vita AA, et al. Nutrients. 2024 Mar 8;16(6):773. doi: 10.3390/nu16060773. Nutrients. 2024. PMID: 38542685 Free PMC article. - A Cohort Study of the Influence of the 12-Component Modified Japanese Diet Index on Oral and Gut Microbiota in the Japanese General Population.
Sato S, Chinda D, Iino C, Sawada K, Mikami T, Nakaji S, Sakuraba H, Fukuda S. Sato S, et al. Nutrients. 2024 Feb 13;16(4):524. doi: 10.3390/nu16040524. Nutrients. 2024. PMID: 38398848 Free PMC article. - Inulin-type fructans and 2'fucosyllactose alter both microbial composition and appear to alleviate stress-induced mood state in a working population compared to placebo (maltodextrin): the EFFICAD Trial, a randomized, controlled trial.
Jackson PP, Wijeyesekera A, Williams CM, Theis S, van Harsselaar J, Rastall RA. Jackson PP, et al. Am J Clin Nutr. 2023 Nov;118(5):938-955. doi: 10.1016/j.ajcnut.2023.08.016. Epub 2023 Aug 30. Am J Clin Nutr. 2023. PMID: 37657523 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous