MicroRNAs add a new dimension to cardiovascular disease - PubMed (original) (raw)

Figure 1

Regulated miRNAs in cardiovascular disease. Disease state is listed in top row and the particular study for each column is stated below. Heat map illustrates level of up-or down-regulation based on color scheme in legend. All miRNAs that were similarly regulated in at least two independent studies are listed to the left of the heat map. The last column lists the most abundant cardiac miRNAs in order of expression level in mice, which might be slightly different from the expression in humans. miRNAs with the same seed region (nucleotides 2-8) were combined into families due to putatively similar functions and due to technical difficulties in distinguishing very similar miRNAs with micro-arrays, northern-blotting or real-time PCR. The family was labeled as regulated if at least one member was changed. Let-7 family, let-7b,c,d,e,f,g,h,i,j; miR-15 family, miR-15a,b/16/195/424/497, miR-29 family, miR-29a,b,c; miR-30 family, miR-30a,b,c,d,e; miR-17 family, miR-17-5p/20a,b/93/106a,b. TAC, thoracic aortic constriction; MI, myocardial infarction; BZ, border zone; RM, remote myocardium; HF, heart failure; DCM, dilated cardiomyopathy; ICM, ischemic cardiomyopathy; AS, aortic stenosis; CAA, carotid artery angioplasty.