Histone variants--ancient wrap artists of the epigenome - PubMed (original) (raw)
Review
doi: 10.1038/nrm2861. Epub 2010 Mar 3.
Affiliations
- PMID: 20197778
- DOI: 10.1038/nrm2861
Review
Histone variants--ancient wrap artists of the epigenome
Paul B Talbert et al. Nat Rev Mol Cell Biol. 2010 Apr.
Abstract
Histones wrap DNA to form nucleosome particles that compact eukaryotic genomes. Variant histones have evolved crucial roles in chromosome segregation, transcriptional regulation, DNA repair, sperm packaging and other processes. 'Universal' histone variants emerged early in eukaryotic evolution and were later displaced for bulk packaging roles by the canonical histones (H2A, H2B, H3 and H4), the synthesis of which is coupled to DNA replication. Further specializations of histone variants have evolved in some lineages to perform additional tasks. Differences among histone variants in their stability, DNA wrapping, specialized domains that regulate access to DNA, and post-translational modifications, underlie the diverse functions that histones have acquired in evolution.
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References
- Genes Dev. 2008 Oct 1;22(19):2633-8 - PubMed
- Mol Cell Biol. 2006 Feb;26(4):1518-26 - PubMed
- FASEB J. 2008 Jan;22(1):316-26 - PubMed
- Cell. 2007 Feb 23;128(4):693-705 - PubMed
- Genes Dev. 2009 May 1;23(9):1037-41 - PubMed
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