Radiotherapy and anaemia--the clinical experience - PubMed (original) (raw)
Review
Radiotherapy and anaemia--the clinical experience
S Dische. Radiother Oncol. 1991.
Abstract
Review of the literature shows good evidence of an impaired outlook for anaemic compared with apparently similar, but non-anaemic patients, treated by radiotherapy for tumors at a number of sites. Some of the adverse associations, may be because anaemic patients, compared with the non-anaemic at the same site and with the same clinical stage, may have in actuality a more advanced disease. However, there is good evidence, especially in carcinoma of the cervix, that there occurs an impairment of the response of tumor to radiotherapy in anaemic patients. Where cure is the object of radiotherapy, restoration of the haemoglobin level is necessary before the course is begun. During the past 60 years there has been much interest in the relationship between anaemia and response to radiotherapy. In 25 series of cases where an effect of anaemia has been sought an adverse influence has been found in 23. An examination of these papers, however, reveals a complex pattern demanding some analysis. Anaemia itself requires definition. As can be seen in Fig. 1, there are different normal ranges for men and women and there is some variation in what is accepted as normal. Haemoglobin levels are commonly given in g%, but they are also expressed as mmol/l. There are also reports which refer to the haematocrit. The haemoglobin value at first presentation may be recorded, but the picture may change by the time treatment is instituted, either because of haemorrhage or because of blood transfusion. In examining reports it is sometimes not easy to know which value is related to response.(ABSTRACT TRUNCATED AT 250 WORDS)
Similar articles
- Anaemia as a prognostic factor for the therapeutic effect of radiosensitizers.
Révész L, Balmukhanov SB. Révész L, et al. Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Apr;51(4):591-5. doi: 10.1080/09553008414552121. Int J Radiat Biol Relat Stud Phys Chem Med. 1987. PMID: 3495505 Clinical Trial. - EORTC guidelines for the use of erythropoietic proteins in anaemic patients with cancer: 2006 update.
Bokemeyer C, Aapro MS, Courdi A, Foubert J, Link H, Osterborg A, Repetto L, Soubeyran P; European Organisation for Research and Treatment of Cancer (EORTC) Taskforce for the Elderly. Bokemeyer C, et al. Eur J Cancer. 2007 Jan;43(2):258-70. doi: 10.1016/j.ejca.2006.10.014. Epub 2006 Dec 19. Eur J Cancer. 2007. PMID: 17182241 Review. - What is the importance of anaemia in radiotherapy? The value of animal studies.
Hirst DG. Hirst DG. Radiother Oncol. 1991;20 Suppl 1:29-33. doi: 10.1016/0167-8140(91)90183-h. Radiother Oncol. 1991. PMID: 2020766 - Carcinoma of the cervix--anaemia, radiotherapy and hyperbaric oxygen.
Dische S, Anderson PJ, Sealy R, Watson ER. Dische S, et al. Br J Radiol. 1983 Apr;56(664):251-5. doi: 10.1259/0007-1285-56-664-251. Br J Radiol. 1983. PMID: 6831148 - EORTC guidelines for the use of erythropoietic proteins in anaemic patients with cancer.
Bokemeyer C, Aapro MS, Courdi A, Foubert J, Link H, Osterborg A, Repetto L, Soubeyran P. Bokemeyer C, et al. Eur J Cancer. 2004 Oct;40(15):2201-16. doi: 10.1016/j.ejca.2004.07.015. Eur J Cancer. 2004. PMID: 15454245 Review.
Cited by
- Primary tumor volume and prognosis for patients with p16-positive and p16-negative oropharyngeal squamous cell carcinoma treated with radiation therapy.
Adrian G, Carlsson H, Kjellén E, Sjövall J, Zackrisson B, Nilsson P, Gebre-Medhin M. Adrian G, et al. Radiat Oncol. 2022 Jun 14;17(1):107. doi: 10.1186/s13014-022-02074-7. Radiat Oncol. 2022. PMID: 35701827 Free PMC article. - Red Blood Cell Transfusion Practices for Patients With Cervical Cancer Undergoing Radiotherapy.
Zayed S, Nguyen TK, Lin C, Boldt G, Beriwal S, Creutzberg CL, Kamrava M, Mendez LC, Velker V, Doll C, Taggar A, Leung E, D'Souza DP. Zayed S, et al. JAMA Netw Open. 2021 Apr 1;4(4):e213531. doi: 10.1001/jamanetworkopen.2021.3531. JAMA Netw Open. 2021. PMID: 33818620 Free PMC article. - The Role of Prognostic Factors in Salivary Gland Tumors Treated by Surgery and Adjuvant Radio- or Chemoradiotherapy - A Single Institution Experience.
Kordzińska-Cisek I, Cisek P, Grzybowska-Szatkowska L. Kordzińska-Cisek I, et al. Cancer Manag Res. 2020 Feb 11;12:1047-1067. doi: 10.2147/CMAR.S233431. eCollection 2020. Cancer Manag Res. 2020. PMID: 32104086 Free PMC article. - Hypoxia and radiation therapy: past history, ongoing research, and future promise.
Rockwell S, Dobrucki IT, Kim EY, Marrison ST, Vu VT. Rockwell S, et al. Curr Mol Med. 2009 May;9(4):442-58. doi: 10.2174/156652409788167087. Curr Mol Med. 2009. PMID: 19519402 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous