MicroRNA control of signal transduction - PubMed (original) (raw)

Review

doi: 10.1038/nrm2868. Epub 2010 Mar 10.

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Review

MicroRNA control of signal transduction

Masafumi Inui et al. Nat Rev Mol Cell Biol. 2010 Apr.

Abstract

MicroRNAs (miRNAs) are integral elements in the post-transcriptional control of gene expression. After the identification of hundreds of miRNAs, the challenge is now to understand their specific biological function. Signalling pathways are ideal candidates for miRNA-mediated regulation owing to the sharp dose-sensitive nature of their effects. Indeed, emerging evidence suggests that miRNAs affect the responsiveness of cells to signalling molecules such as transforming growth factor-beta, WNT, Notch and epidermal growth factor. As such, miRNAs serve as nodes of signalling networks that ensure homeostasis and regulate cancer, metastasis, fibrosis and stem cell biology.

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