CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models - PubMed (original) (raw)
Review
doi: 10.1016/j.tins.2010.02.001. Epub 2010 Mar 10.
Affiliations
- PMID: 20223527
- DOI: 10.1016/j.tins.2010.02.001
Free article
Review
CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models
Eva Benito et al. Trends Neurosci. 2010 May.
Free article
Abstract
The activation of cAMP-response element binding protein (CREB)-dependent gene expression seems a crucial step in the molecular cascade that mediates the formation of long-lasting memories. This view is based both on correlative evidence and on functional assays that demonstrate, through loss- and gain-of-function experiments, the impact of CREB manipulation on memory performance. Mechanistically, CREB's role in memory is thought to be a consequence of its participation in long-term forms of synaptic plasticity. Recent studies demonstrate that CREB, in addition to synaptic plasticity, also modulates the intrinsic excitability of the neuron. This discovery reveals new intriguing connections between intrinsic and synaptic plasticity and is likely to have a significant impact on our understanding of the role of CREB in memory formation.
Copyright 2010 Elsevier Ltd. All rights reserved.
Similar articles
- Genetic approaches to investigate the role of CREB in neuronal plasticity and memory.
Barco A, Marie H. Barco A, et al. Mol Neurobiol. 2011 Dec;44(3):330-49. doi: 10.1007/s12035-011-8209-x. Epub 2011 Sep 23. Mol Neurobiol. 2011. PMID: 21948060 Review. - Inhibition of cAMP response element-binding protein reduces neuronal excitability and plasticity, and triggers neurodegeneration.
Jancic D, Lopez de Armentia M, Valor LM, Olivares R, Barco A. Jancic D, et al. Cereb Cortex. 2009 Nov;19(11):2535-47. doi: 10.1093/cercor/bhp004. Epub 2009 Feb 12. Cereb Cortex. 2009. PMID: 19213815 - Brain plasticity mechanisms and memory: a party of four.
Bruel-Jungerman E, Davis S, Laroche S. Bruel-Jungerman E, et al. Neuroscientist. 2007 Oct;13(5):492-505. doi: 10.1177/1073858407302725. Neuroscientist. 2007. PMID: 17901258 Review. - CREB binding and activity in brain: regional specificity and induction by electroconvulsive seizure.
Tanis KQ, Duman RS, Newton SS. Tanis KQ, et al. Biol Psychiatry. 2008 Apr 1;63(7):710-20. doi: 10.1016/j.biopsych.2007.08.003. Epub 2007 Oct 15. Biol Psychiatry. 2008. PMID: 17936724 Free PMC article. - Protein phosphatase 1-dependent transcriptional programs for long-term memory and plasticity.
Gräff J, Koshibu K, Jouvenceau A, Dutar P, Mansuy IM. Gräff J, et al. Learn Mem. 2010 Jun 30;17(7):355-63. doi: 10.1101/lm.1766510. Print 2010 Jul. Learn Mem. 2010. PMID: 20592054
Cited by
- Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF.
Puigdellívol M, Saavedra A, Pérez-Navarro E. Puigdellívol M, et al. Brain Pathol. 2016 Nov;26(6):752-771. doi: 10.1111/bpa.12432. Brain Pathol. 2016. PMID: 27529673 Free PMC article. Review. - Moderate exercise prevents neurodegeneration in D-galactose-induced aging mice.
Li L, Xu M, Shen B, Li M, Gao Q, Wei SG. Li L, et al. Neural Regen Res. 2016 May;11(5):807-15. doi: 10.4103/1673-5374.182709. Neural Regen Res. 2016. PMID: 27335566 Free PMC article. - Genistein Prevents Hypoxia-Induced Cognitive Dysfunctions by Ameliorating Oxidative Stress and Inflammation in the Hippocampus.
Rumman M, Pandey S, Singh B, Gupta M, Ubaid S, Mahdi AA. Rumman M, et al. Neurotox Res. 2021 Aug;39(4):1123-1133. doi: 10.1007/s12640-021-00353-x. Epub 2021 Mar 19. Neurotox Res. 2021. PMID: 33740236 - HDAC4 governs a transcriptional program essential for synaptic plasticity and memory.
Sando R 3rd, Gounko N, Pieraut S, Liao L, Yates J 3rd, Maximov A. Sando R 3rd, et al. Cell. 2012 Nov 9;151(4):821-834. doi: 10.1016/j.cell.2012.09.037. Cell. 2012. PMID: 23141539 Free PMC article. - Involvement of phosphorylated Apis mellifera CREB in gating a honeybee's behavioral response to an external stimulus.
Gehring KB, Heufelder K, Feige J, Bauer P, Dyck Y, Ehrhardt L, Kühnemund J, Bergmann A, Göbel J, Isecke M, Eisenhardt D. Gehring KB, et al. Learn Mem. 2016 Apr 15;23(5):195-207. doi: 10.1101/lm.040964.115. Print 2016 May. Learn Mem. 2016. PMID: 27084927 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical