Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging - PubMed (original) (raw)
Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging
D S Kerr et al. J Neurosci. 1991 May.
Abstract
There is increasing evidence that experimental interventions that alter adrenal corticosteroid plasma concentrations can modulate aging changes in the rodent hippocampus. However, there still is very little evidence that elevation of endogenous corticosteroid levels within physiological ranges, such as occurs during chronic stress, can accelerate hippocampal aging-like changes. In addition, almost all prior intervention studies of corticosteroid effects on brain biomarkers of aging have utilized morphologic measures of aging, and it is not yet clear whether electrophysiologic biomarkers of hippocampal aging can also be accelerated by conditions that elevate corticosteroids. In the present studies, specific pathogen-free rats of three ages (4, 12, and 18 months at the start) were trained for 6 months (4 hr/d, 5 d/week) in a two-way shuttle escape task, using low intensity foot shock. This task induces "anxiety" stress, because animals receive little actual shock, but chronic training in the task has been shown to elevate plasma corticosteroids and to downregulate hippocampal corticosteroid receptors. At the end of 6 months, animals were allowed to recover for 3 weeks and were then assessed in acute, anesthetized preparations on a battery of hippocampal neurophysiological markers known to separate young from aged animals (frequency potentiation, synaptic excitability thresholds, EPSP amplitude). The brains were then fixed and sectioned for quantification of neuronal density in field CA1 (a highly consistent anatomic marker of hippocampal aging). The pattern of stress effects differed considerably across age groups. The two younger stress groups exhibited increased evidence of aging-like neurophysiologic change, but exhibited no indications of accelerated neuronal loss.(ABSTRACT TRUNCATED AT 250 WORDS)
Similar articles
- Alterations in the properties of hippocampal pyramidal neurons in the aged rat.
Potier B, Rascol O, Jazat F, Lamour Y, Dutar P. Potier B, et al. Neuroscience. 1992 Jun;48(4):793-806. doi: 10.1016/0306-4522(92)90267-6. Neuroscience. 1992. PMID: 1630625 - Region-specific age effects on AMPA sensitivity: electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1.
Barnes CA, Rao G, Foster TC, McNaughton BL. Barnes CA, et al. Hippocampus. 1992 Oct;2(4):457-68. doi: 10.1002/hipo.450020413. Hippocampus. 1992. PMID: 1284976 - Apparent age-related resistance of type II hippocampal corticosteroid receptors to down-regulation during chronic escape training.
Eldridge JC, Brodish A, Kute TE, Landfield PW. Eldridge JC, et al. J Neurosci. 1989 Sep;9(9):3237-42. doi: 10.1523/JNEUROSCI.09-09-03237.1989. J Neurosci. 1989. PMID: 2795161 Free PMC article. - The effects of high Mg2+-to-Ca2+ ratios on frequency potentiation in hippocampal slices of young and aged rats.
Landfield PW, Pitler TA, Applegate MD. Landfield PW, et al. J Neurophysiol. 1986 Sep;56(3):797-811. doi: 10.1152/jn.1986.56.3.797. J Neurophysiol. 1986. PMID: 3783221 - Synaptic vesicle redistribution during hippocampal frequency potentiation and depression in young and aged rats.
Applegate MD, Landfield PW. Applegate MD, et al. J Neurosci. 1988 Apr;8(4):1096-111. doi: 10.1523/JNEUROSCI.08-04-01096.1988. J Neurosci. 1988. PMID: 3357011 Free PMC article.
Cited by
- Cellular and molecular mechanisms of hippocampal activation by acute stress are age-dependent.
Chen Y, Fenoglio KA, Dubé CM, Grigoriadis DE, Baram TZ. Chen Y, et al. Mol Psychiatry. 2006 Nov;11(11):992-1002. doi: 10.1038/sj.mp.4001863. Epub 2006 Jun 27. Mol Psychiatry. 2006. PMID: 16801951 Free PMC article. - Elevated cortisol and learning and memory deficits in cocaine dependent individuals: relationship to relapse outcomes.
Fox HC, Jackson ED, Sinha R. Fox HC, et al. Psychoneuroendocrinology. 2009 Sep;34(8):1198-207. doi: 10.1016/j.psyneuen.2009.03.007. Epub 2009 Apr 16. Psychoneuroendocrinology. 2009. PMID: 19375236 Free PMC article. - Neuropathology of stress.
Lucassen PJ, Pruessner J, Sousa N, Almeida OF, Van Dam AM, Rajkowska G, Swaab DF, Czéh B. Lucassen PJ, et al. Acta Neuropathol. 2014 Jan;127(1):109-35. doi: 10.1007/s00401-013-1223-5. Epub 2013 Dec 8. Acta Neuropathol. 2014. PMID: 24318124 Free PMC article. Review. - Adrenal steroids and plasticity of hippocampal neurons: toward an understanding of underlying cellular and molecular mechanisms.
McEwen BS, Cameron H, Chao HM, Gould E, Magarinos AM, Watanabe Y, Woolley CS. McEwen BS, et al. Cell Mol Neurobiol. 1993 Aug;13(4):457-82. doi: 10.1007/BF00711583. Cell Mol Neurobiol. 1993. PMID: 8252613 Review. No abstract available. - The CRF₁ receptor antagonist SSR125543 prevents stress-induced cognitive deficit associated with hippocampal dysfunction: comparison with paroxetine and D-cycloserine.
Philbert J, Belzung C, Griebel G. Philbert J, et al. Psychopharmacology (Berl). 2013 Jul;228(1):97-107. doi: 10.1007/s00213-013-3020-1. Epub 2013 Feb 14. Psychopharmacology (Berl). 2013. PMID: 23407783
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous