The effect of the interleukin-1 cytokine family members IL-1F6 and IL-1F8 on adipocyte differentiation - PubMed (original) (raw)

. 2010 Nov;18(11):2234-6.

doi: 10.1038/oby.2010.55. Epub 2010 Mar 18.

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The effect of the interleukin-1 cytokine family members IL-1F6 and IL-1F8 on adipocyte differentiation

Edwin J P van Asseldonk et al. Obesity (Silver Spring). 2010 Nov.

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Abstract

Obesity is characterized by chronic low-grade inflammation originating from expanding adipose tissue. In the present study, we examined the adipogenic expression levels of IL-1F6 and IL-1F8, both members of the IL-1 family of cytokines, and their effects on adipose tissue gene expression. Although IL-1F6 is primarily present in adipose tissue resident macrophages and induced by inflammation, IL-1F8 is absent. IL-1F6, but not IL-1F8, reduces adipocyte differentiation, as shown by a significant decrease in PPARγ gene expression. Finally, both IL-1F6 and IL-1F8 are able to induce inflammatory gene expression in mature adipocytes. In conclusion, we demonstrate for the first time that IL-1F6 is present in adipose tissue and that IL-1F6 and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-1F6 inhibits PPARγ expression which may lead to reduced adipocyte differentiation suggesting metabolic effects of this cytokine.

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