Polymeric micelles as a drug delivery system enhance cytotoxicity of vinorelbine through more intercellular accumulation - PubMed (original) (raw)

Comparative Study

Polymeric micelles as a drug delivery system enhance cytotoxicity of vinorelbine through more intercellular accumulation

Xiaoyan Lu et al. Drug Deliv. 2010 May.

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Abstract

Polymeric micelles had been used as an efficacious carrier system for anti-cancer drug delivery. However, it is not clear whether the molecular mechanism of drug encapsulated in micelles is same as free drug. In this study, the mechanism of vinorelbine loaded in glycol-phosphatidylethanolamine (PEG-PE) micelles (M-Vino) on tumor cells was investigated. Compared with free vinorelbine (Free Vino), M-Vino was more effective in inhibiting the growth of tumor cells in vitro, inducing G(2)/M phase arrest and apoptosis of tumor cells. M-Vino showed a faster entry and higher accumulation in 4T1 cells than free vinorelbine. Therefore, M-Vino destabilized microtubules, induced cell death, and enhanced its cytotoxicity through more intercellular accumulation of vinorelbine.

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