Male development of chromosomally female mice transgenic for Sry - PubMed (original) (raw)

. 1991 May 9;351(6322):117-21.

doi: 10.1038/351117a0.

Affiliations

• PMID: 2030730
• DOI: 10.1038/351117a0

Male development of chromosomally female mice transgenic for Sry

P Koopman et al. Nature. 1991.

Abstract

The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.

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Comment in

• Sex determination. The making of male mice.
  McLaren A. McLaren A. Nature. 1991 May 9;351(6322):96. doi: 10.1038/351096a0. Nature. 1991. PMID: 2030741 No abstract available.

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