Immunology of pre-eclampsia - PubMed (original) (raw)
Review
Immunology of pre-eclampsia
Christopher W G Redman et al. Am J Reprod Immunol. 2010 Jun.
Abstract
Pre-eclampsia develops in stages, only the last being the clinical illness. This is generated by a non-specific, systemic (vascular), inflammatory response, secondary to placental oxidative stress and not by reactivity to fetal alloantigens. However, maternal adaptation to fetal (paternal alloantigens) is crucial in the earlier stages. A pre-conceptual phase involves maternal tolerization to paternal antigens by seminal plasma. After conception, regulatory T cells, interacting with indoleamine 2,3-dioxygenase, together with decidual NK cell recognition of fetal HLA-C on extravillous trophoblast may facilitate placental growth by immunoregulation. Complete failure of this mechanism would cause miscarriage, while partial failure would cause poor placentation and dysfunctional uteroplacental perfusion. The first pregnancy preponderance and partner specificity of pre-eclampsia can be explained by this model. For the first time, the pathogenesis of pre-eclampsia can be related to defined immune mechanisms that are appropriate to the fetomaternal frontier. Now, the challenge is to prove the detail.
Similar articles
- How Does the maternal immune system contribute to the development of pre-eclampsia?
Moffett A, Hiby SE. Moffett A, et al. Placenta. 2007 Apr;28 Suppl A:S51-6. doi: 10.1016/j.placenta.2006.11.008. Epub 2007 Feb 8. Placenta. 2007. PMID: 17292469 - Aberrant uterine natural killer (NK)-cell expression and altered placental and serum levels of the NK-cell promoting cytokine interleukin-12 in pre-eclampsia.
Bachmayer N, Rafik Hamad R, Liszka L, Bremme K, Sverremark-Ekström E. Bachmayer N, et al. Am J Reprod Immunol. 2006 Nov-Dec;56(5-6):292-301. doi: 10.1111/j.1600-0897.2006.00429.x. Am J Reprod Immunol. 2006. PMID: 17076673 - HLA Class I protein expression in the human placenta.
Blaschitz A, Hutter H, Dohr G. Blaschitz A, et al. Early Pregnancy (Cherry Hill). 2001 Jan;5(1):67-9. Early Pregnancy (Cherry Hill). 2001. PMID: 11753519 - NK cells and pre-eclampsia.
Sargent IL, Borzychowski AM, Redman CW. Sargent IL, et al. J Reprod Immunol. 2007 Dec;76(1-2):40-4. doi: 10.1016/j.jri.2007.03.009. Epub 2007 May 4. J Reprod Immunol. 2007. PMID: 17482272 Review. - Latest advances in understanding preeclampsia.
Redman CW, Sargent IL. Redman CW, et al. Science. 2005 Jun 10;308(5728):1592-4. doi: 10.1126/science.1111726. Science. 2005. PMID: 15947178 Review.
Cited by
- Maternal and fetal neurocognitive outcomes in preeclampsia and eclampsia; a narrative review of current evidence.
Kokori E, Aderinto N, Olatunji G, Komolafe R, Abraham IC, Babalola AE, Aboje JE, Ukoaka BM, Samuel O, Ayodeji A, Omoworare O, Olatunji D. Kokori E, et al. Eur J Med Res. 2024 Sep 28;29(1):470. doi: 10.1186/s40001-024-02070-5. Eur J Med Res. 2024. PMID: 39342384 Free PMC article. Review. - Metabolic theory of preeclampsia: implications for maternal cardiovascular health.
Manoharan MM, Montes GC, Acquarone M, Swan KF, Pridjian GC, Nogueira Alencar AK, Bayer CL. Manoharan MM, et al. Am J Physiol Heart Circ Physiol. 2024 Sep 1;327(3):H582-H597. doi: 10.1152/ajpheart.00170.2024. Epub 2024 Jul 5. Am J Physiol Heart Circ Physiol. 2024. PMID: 38968164 Review. - Role of hematological indices in predicting preeclampsia and its severity: retrospective case-control study.
Al-Nuaimi AMA. Al-Nuaimi AMA. Medicine (Baltimore). 2024 Jun 21;103(25):e38557. doi: 10.1097/MD.0000000000038557. Medicine (Baltimore). 2024. PMID: 38905404 Free PMC article. - Decidual γδT cells of early human pregnancy produce angiogenic and immunomodulatory proteins while also possessing cytotoxic potential.
Nörenberg J, Vida P, Bösmeier I, Forró B, Nörenberg A, Buda Á, Simon D, Erdő-Bonyár S, Jáksó P, Kovács K, Mikó É, Berki T, Mezősi E, Barakonyi A. Nörenberg J, et al. Front Immunol. 2024 Mar 27;15:1382424. doi: 10.3389/fimmu.2024.1382424. eCollection 2024. Front Immunol. 2024. PMID: 38601161 Free PMC article. - Protective role of complement factor H against the development of preeclampsia.
Yasmin H, Agostinis C, Toffoli M, Roy T, Pegoraro S, Balduit A, Zito G, Di Simone N, Ricci G, Madan T, Kishore U, Bulla R. Yasmin H, et al. Front Immunol. 2024 Feb 23;15:1351898. doi: 10.3389/fimmu.2024.1351898. eCollection 2024. Front Immunol. 2024. PMID: 38464530 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials