Xenopus RCOR2 (REST corepressor 2) interacts with ZMYND8, which is involved in neural differentiation - PubMed (original) (raw)

. 2010 Apr 16;394(4):1024-9.

doi: 10.1016/j.bbrc.2010.03.115. Epub 2010 Mar 21.

Affiliations

• PMID: 20331974
• DOI: 10.1016/j.bbrc.2010.03.115

Xenopus RCOR2 (REST corepressor 2) interacts with ZMYND8, which is involved in neural differentiation

Wanli Zeng et al. Biochem Biophys Res Commun. 2010.

Abstract

Regulation of neuronal gene expression is critical to nervous system development. REST (RE1-silencing transcription factor) regulates neuronal gene expression through interacting with a group of corepressor proteins including REST corepressors (RCOR). Here we show that Xenopus RCOR2 is predominantly expressed in the developing nervous system. Through a yeast two-hybrid screen, we isolated Xenopus ZMYND8 (Zinc finger and MYND domain containing 8) as an XRCOR2 interacting factor. XRCOR2 and XZMYND8 bind each other in co-immunoprecipitation assays and both of them can function as transcriptional repressors. XZMYND8 is co-expressed with XRCOR2 in the nervous system and overexpression of XZMYND8 inhibits neural differentiation in Xenopus embryos. These data reveal a RCOR2/ZMYND8 complex which might be involved in the regulation of neural differentiation.

2010 Elsevier Inc. All rights reserved.

PubMed Disclaimer

Similar articles

• Xenopus Dbx2 is involved in primary neurogenesis and early neural plate patterning.
  Ma P, Zhao S, Zeng W, Yang Q, Li C, Lv X, Zhou Q, Mao B. Ma P, et al. Biochem Biophys Res Commun. 2011 Aug 19;412(1):170-4. doi: 10.1016/j.bbrc.2011.07.068. Epub 2011 Jul 23. Biochem Biophys Res Commun. 2011. PMID: 21806971
• Two Hoxc6 transcripts are differentially expressed and regulate primary neurogenesis in Xenopus laevis.
  Bardine N, Donow C, Korte B, Durston AJ, Knöchel W, Wacker SA. Bardine N, et al. Dev Dyn. 2009 Mar;238(3):755-65. doi: 10.1002/dvdy.21889. Dev Dyn. 2009. PMID: 19235717
• Frizzled-10 promotes sensory neuron development in Xenopus embryos.
  Garcia-Morales C, Liu CH, Abu-Elmagd M, Hajihosseini MK, Wheeler GN. Garcia-Morales C, et al. Dev Biol. 2009 Nov 1;335(1):143-55. doi: 10.1016/j.ydbio.2009.08.021. Epub 2009 Aug 28. Dev Biol. 2009. PMID: 19716814
• No rest for REST: REST/NRSF regulation of neurogenesis.
  Lunyak VV, Rosenfeld MG. Lunyak VV, et al. Cell. 2005 May 20;121(4):499-501. doi: 10.1016/j.cell.2005.05.003. Cell. 2005. PMID: 15907461 Review.
• Post-transcriptional regulation in Xenopus embryos: role and targets of EDEN-BP.
  Osborne HB, Gautier-Courteille C, Graindorge A, Barreau C, Audic Y, Thuret R, Pollet N, Paillard L. Osborne HB, et al. Biochem Soc Trans. 2005 Dec;33(Pt 6):1541-3. doi: 10.1042/BST0331541. Biochem Soc Trans. 2005. PMID: 16246165 Review.

Cited by

• Casein kinase 1 promotes synchrony of the circadian clock network.
  Zheng X, Sowcik M, Chen D, Sehgal A. Zheng X, et al. Mol Cell Biol. 2014 Jul;34(14):2682-94. doi: 10.1128/MCB.01571-13. Mol Cell Biol. 2014. PMID: 24820422 Free PMC article.
• Regulation of ZMYND8 to Treat Cancer.
  Chen Y, Tsai YH, Tseng SH. Chen Y, et al. Molecules. 2021 Feb 18;26(4):1083. doi: 10.3390/molecules26041083. Molecules. 2021. PMID: 33670804 Free PMC article. Review.
• Analysis of the human endogenous coregulator complexome.
  Malovannaya A, Lanz RB, Jung SY, Bulynko Y, Le NT, Chan DW, Ding C, Shi Y, Yucer N, Krenciute G, Kim BJ, Li C, Chen R, Li W, Wang Y, O'Malley BW, Qin J. Malovannaya A, et al. Cell. 2011 May 27;145(5):787-99. doi: 10.1016/j.cell.2011.05.006. Cell. 2011. PMID: 21620140 Free PMC article.
• A novel role of tumor suppressor ZMYND8 in inducing differentiation of breast cancer cells through its dual-histone binding function.
  Mukherjee S, Sen S, Adhikary S, Sengupta A, Mandal P, Dasgupta D, Chakrabarti P, Roy S, DAS C. Mukherjee S, et al. J Biosci. 2020;45:2. J Biosci. 2020. PMID: 31965980
• Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation.
  Sáez JE, Gómez AV, Barrios ÁP, Parada GE, Galdames L, González M, Andrés ME. Sáez JE, et al. PLoS One. 2015 Jun 25;10(6):e0131760. doi: 10.1371/journal.pone.0131760. eCollection 2015. PLoS One. 2015. PMID: 26111147 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Molecular Biology Databases

  • Gene Ontology