Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg) - PubMed (original) (raw)
. 2010 May;91(5):1348-58.
doi: 10.3945/ajcn.2009.28691. Epub 2010 Mar 24.
Affiliations
- PMID: 20335553
- DOI: 10.3945/ajcn.2009.28691
Free article
Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)
Katharina Nimptsch et al. Am J Clin Nutr. 2010 May.
Free article
Abstract
Background: Anticarcinogenic activities of vitamin K have been observed in animal and cell studies.
Objective: On the basis of the growth inhibitory effects of vitamin K as observed in a variety of cancer cell lines, we hypothesized that dietary intake of phylloquinone (vitamin K(1)) and menaquinones (vitamin K(2)) may be associated with overall cancer incidence and mortality.
Design: In the prospective EPIC-Heidelberg (European Prospective Investigation into Cancer and Nutrition-Heidelberg) cohort study, 24,340 participants aged 35-64 y and free of cancer at enrollment (1994-1998) were actively followed up for cancer incidence and mortality through 2008. Dietary vitamin K intake was estimated from food-frequency questionnaires completed at baseline by using HPLC-based food-composition data. Multivariate-adjusted hazard ratios (HRs) and 95% CIs were estimated by using Cox proportional hazards models.
Results: During a median follow-up time of >10 y, 1755 incident cancer cases occurred, of which 458 were fatal. Dietary intake of menaquinones was nonsignificantly inversely associated with overall cancer incidence (HR for the highest compared with the lowest quartile: 0.86; 95% CI: 0.73, 1.01; P for trend = 0.08), and the association was stronger for cancer mortality (HR: 0.72; 95% CI: 0.53, 0.98; P for trend = 0.03). Cancer risk reduction with increasing intake of menaquinones was more pronounced in men than in women, mainly driven by significant inverse associations with prostate (P for trend = 0.03) and lung (P for trend = 0.002) cancer. We found no association with phylloquinone intake.
Conclusion: These findings suggest that dietary intake of menaquinones, which is highly determined by the consumption of cheese, is associated with a reduced risk of incident and fatal cancer.
Comment in
- Dietary intake of menaquinones and risk of cancer incidence and mortality.
Chow CK. Chow CK. Am J Clin Nutr. 2010 Dec;92(6):1533-4; author reply 1534-5. doi: 10.3945/ajcn.110.002337. Epub 2010 Sep 29. Am J Clin Nutr. 2010. PMID: 20881065 No abstract available.
Similar articles
- Vitamin K intake and all-cause and cause specific mortality.
Zwakenberg SR, den Braver NR, Engelen AIP, Feskens EJM, Vermeer C, Boer JMA, Verschuren WMM, van der Schouw YT, Beulens JWJ. Zwakenberg SR, et al. Clin Nutr. 2017 Oct;36(5):1294-1300. doi: 10.1016/j.clnu.2016.08.017. Epub 2016 Aug 30. Clin Nutr. 2017. PMID: 27640076 - The relationship between vitamin K and peripheral arterial disease.
Vissers LET, Dalmeijer GW, Boer JMA, Verschuren WMM, van der Schouw YT, Beulens JWJ. Vissers LET, et al. Atherosclerosis. 2016 Sep;252:15-20. doi: 10.1016/j.atherosclerosis.2016.07.915. Epub 2016 Jul 25. Atherosclerosis. 2016. PMID: 27494446 - Menaquinones, bacteria, and the food supply: the relevance of dairy and fermented food products to vitamin K requirements.
Walther B, Karl JP, Booth SL, Boyaval P. Walther B, et al. Adv Nutr. 2013 Jul 1;4(4):463-73. doi: 10.3945/an.113.003855. Adv Nutr. 2013. PMID: 23858094 Free PMC article. Review. - New insights into vitamin K biology with relevance to cancer.
Welsh J, Bak MJ, Narvaez CJ. Welsh J, et al. Trends Mol Med. 2022 Oct;28(10):864-881. doi: 10.1016/j.molmed.2022.07.002. Epub 2022 Aug 23. Trends Mol Med. 2022. PMID: 36028390 Free PMC article. Review.
Cited by
- Menaquinone-4 Alleviates Sepsis-Associated Acute Lung Injury via Activating SIRT3-p53/SLC7A11 Pathway.
Gao N, Liu XY, Chen J, Hu TP, Wang Y, Zhang GQ. Gao N, et al. J Inflamm Res. 2024 Oct 24;17:7675-7685. doi: 10.2147/JIR.S486984. eCollection 2024. J Inflamm Res. 2024. PMID: 39469061 Free PMC article. - Menaquinone-4 Suppresses Lipopolysaccharide-Induced Inflammation in MG6 Mouse Microglia-Derived Cells by Inhibiting the NF-κB Signaling Pathway.
Saputra WD, Aoyama N, Komai M, Shirakawa H. Saputra WD, et al. Int J Mol Sci. 2019 May 10;20(9):2317. doi: 10.3390/ijms20092317. Int J Mol Sci. 2019. PMID: 31083359 Free PMC article. - Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease.
Piscaer I, van den Ouweland JMW, Vermeersch K, Reynaert NL, Franssen FME, Keene S, Wouters EFM, Janssens W, Vermeer C, Janssen R. Piscaer I, et al. J Clin Med. 2019 Jul 27;8(8):1116. doi: 10.3390/jcm8081116. J Clin Med. 2019. PMID: 31357639 Free PMC article. - An atlas of associations between 14 micronutrients and 22 cancer outcomes: Mendelian randomization analyses.
Kim JY, Song M, Kim MS, Natarajan P, Do R, Myung W, Won HH. Kim JY, et al. BMC Med. 2023 Aug 21;21(1):316. doi: 10.1186/s12916-023-03018-y. BMC Med. 2023. PMID: 37605270 Free PMC article. - Vitamin K2, a menaquinone present in dairy products targets castration-resistant prostate cancer cell-line by activating apoptosis signaling.
Dasari S, Samy ALPA, Kajdacsy-Balla A, Bosland MC, Munirathinam G. Dasari S, et al. Food Chem Toxicol. 2018 May;115:218-227. doi: 10.1016/j.fct.2018.02.018. Epub 2018 Feb 9. Food Chem Toxicol. 2018. PMID: 29432837 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical