The genetics of ageing - PubMed (original) (raw)

Review

. 2010 Mar 25;464(7288):504-12.

doi: 10.1038/nature08980.

Affiliations

• PMID: 20336132
• DOI: 10.1038/nature08980

Review

The genetics of ageing

Cynthia J Kenyon. Nature. 2010.

Erratum in

• Nature. 2010 Sep 30;467(7315):622

Abstract

The nematode Caenorhabditis elegans ages and dies in a few weeks, but humans can live for 100 years or more. Assuming that the ancestor we share with nematodes aged rapidly, this means that over evolutionary time mutations have increased lifespan more than 2,000-fold. Which genes can extend lifespan? Can we augment their activities and live even longer? After centuries of wistful poetry and wild imagination, we are now getting answers, often unexpected ones, to these fundamental questions.

PubMed Disclaimer

Similar articles

• Genetics: influence of TOR kinase on lifespan in C. elegans.
  Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Müller F. Vellai T, et al. Nature. 2003 Dec 11;426(6967):620. doi: 10.1038/426620a. Nature. 2003. PMID: 14668850 No abstract available.
• The cell biology of aging.
  DiLoreto R, Murphy CT. DiLoreto R, et al. Mol Biol Cell. 2015 Dec 15;26(25):4524-31. doi: 10.1091/mbc.E14-06-1084. Mol Biol Cell. 2015. PMID: 26668170 Free PMC article. Review.
• Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.
  Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C. Murphy CT, et al. Nature. 2003 Jul 17;424(6946):277-83. doi: 10.1038/nature01789. Epub 2003 Jun 29. Nature. 2003. PMID: 12845331
• [Signal pathway of insulin and insulin-like growth factor 1 (IGF-1) as a potential regulator of lifespan].
  Chistiakova OV. Chistiakova OV. Zh Evol Biokhim Fiziol. 2008 Jan-Feb;44(1):3-11. Zh Evol Biokhim Fiziol. 2008. PMID: 18411507 Review. Russian.
• The trifecta of aging in Caenorhabditis elegans.
  Wolff S, Dillin A. Wolff S, et al. Exp Gerontol. 2006 Oct;41(10):894-903. doi: 10.1016/j.exger.2006.06.054. Epub 2006 Aug 21. Exp Gerontol. 2006. PMID: 16919905 Review.

Cited by

• The evolution of ageing: classic theories and emerging ideas.
  Mc Auley MT. Mc Auley MT. Biogerontology. 2024 Oct 29;26(1):6. doi: 10.1007/s10522-024-10143-5. Biogerontology. 2024. PMID: 39470884 Free PMC article. Review.
• Disruption of tRNA biogenesis enhances proteostatic resilience, improves later-life health, and promotes longevity.
  Malik Y, Kulaberoglu Y, Anver S, Javidnia S, Borland G, Rivera R, Cranwell S, Medelbekova D, Svermova T, Thomson J, Broughton S, von der Haar T, Selman C, Tullet JMA, Alic N. Malik Y, et al. PLoS Biol. 2024 Oct 22;22(10):e3002853. doi: 10.1371/journal.pbio.3002853. eCollection 2024 Oct. PLoS Biol. 2024. PMID: 39436952 Free PMC article.
• Depletion of loss-of-function germline mutations in centenarians reveals longevity genes.
  Ying K, Castro JP, Shindyapina AV, Tyshkovskiy A, Moqri M, Goeminne LJE, Milman S, Zhang ZD, Barzilai N, Gladyshev VN. Ying K, et al. Nat Commun. 2024 Oct 19;15(1):9030. doi: 10.1038/s41467-024-52967-2. Nat Commun. 2024. PMID: 39424787 Free PMC article.
• Structural and physiological functions of Caenorhabditis elegans epidermis.
  Wang E, Jiang Y, Zhao C. Wang E, et al. Heliyon. 2024 Sep 28;10(19):e38680. doi: 10.1016/j.heliyon.2024.e38680. eCollection 2024 Oct 15. Heliyon. 2024. PMID: 39397934 Free PMC article. Review.

References

1. 1. Neurobiol Aging. 2009 Sep;30(9):1498-503 - PubMed
2. 1. Autophagy. 2008 Apr;4(3):330-8 - PubMed
3. 1. Science. 2005 Dec 23;310(5756):1954-7 - PubMed
4. 1. Annu Rev Genomics Hum Genet. 2009;10:153-74 - PubMed
5. 1. PLoS Genet. 2009 Apr;5(4):e1000460 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information