Abdominal subcutaneous and visceral adipose tissue and insulin resistance in the Framingham heart study - PubMed (original) (raw)
Abdominal subcutaneous and visceral adipose tissue and insulin resistance in the Framingham heart study
Sarah R Preis et al. Obesity (Silver Spring). 2010 Nov.
Abstract
Insulin resistance is associated with central obesity and an increased risk of cardiovascular disease. Our objective is to examine the association between abdominal subcutaneous (SAT) and visceral adipose tissue (VAT) and insulin resistance, to determine which fat depot is a stronger correlate of insulin resistance, and to assess whether there was an interaction between SAT, VAT, and age, sex, or BMI. Participants without diabetes from the Framingham Heart Study (FHS), who underwent multidetector computed tomography to assess SAT and VAT (n = 3,093; 48% women; mean age 50.4 years; mean BMI 27.6 kg/m(2)), were evaluated. Insulin resistance was measured using the homeostasis model and defined as HOMA(IR) ≥75th percentile. Logistic regression models, adjusted for age, sex, smoking, alcohol, menopausal status, and hormone replacement therapy use, were used to assess the association between fat measures and insulin resistance. The odds ratio (OR) for insulin resistance per standard deviation increase in SAT was 2.5 (95% confidence interval (CI): 2.2-2.7; P < 0.0001), whereas the OR for insulin resistance per standard deviation increase in VAT was 3.5 (95% CI: 3.1-3.9; P < 0.0001). Overall, VAT was a stronger correlate of insulin resistance than SAT (P < 0.0001 for SAT vs. VAT comparison). After adjustment for BMI, the OR of insulin resistance for VAT was 2.2 (95% CI: 1.9-2.5; P < 0.0001). We observed an interaction between VAT and BMI for insulin (P interaction = 0.0004), proinsulin (P interaction = 0.003), and HOMA(IR) (P interaction = 0.003), where VAT had a stronger association in obese individuals. In conclusion, SAT and VAT are both correlates of insulin resistance; however, VAT is a stronger correlate of insulin resistance than SAT.
Figures
Figure 1
Multivariable-adjusted mean insulin variables by tertiles of abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). HOMAIR, homeostasis model assessment of insulin resistance. Note: Bars represent 95% confidence intervals. *Adjusted for age, sex, current smoking, regular alcohol consumption, menopausal status, and hormone replacement therapy use. †Median values of SAT: tertile 1 (men, 1,597 cm3; women, 1,722 cm3); tertile 2 (men, 2,401 cm3; women, 2,861 cm3); tertile 3 (men, 3,600 cm3; women, 4,656 cm3). ‡P interaction refers to the interaction between SAT and VAT. §Median values of VAT: tertile 1 (men, 1,234 cm3; women, 543 cm3); tertile 2 (men, 2,092 cm3; women, 1,180 cm3); tertile 3 (men, 3,127 cm3; women, 2,104 cm3).
Similar articles
- Associations of Abdominal Subcutaneous and Visceral Fat with Insulin Resistance and Secretion Differ Between Men and Women: The Netherlands Epidemiology of Obesity Study.
de Mutsert R, Gast K, Widya R, de Koning E, Jazet I, Lamb H, le Cessie S, de Roos A, Smit J, Rosendaal F, den Heijer M. de Mutsert R, et al. Metab Syndr Relat Disord. 2018 Feb;16(1):54-63. doi: 10.1089/met.2017.0128. Epub 2018 Jan 17. Metab Syndr Relat Disord. 2018. PMID: 29338526 - Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study.
Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, Vasan RS, Murabito JM, Meigs JB, Cupples LA, D'Agostino RB Sr, O'Donnell CJ. Fox CS, et al. Circulation. 2007 Jul 3;116(1):39-48. doi: 10.1161/CIRCULATIONAHA.106.675355. Epub 2007 Jun 18. Circulation. 2007. PMID: 17576866 - Gender differences in the association of visceral and subcutaneous adiposity with adiponectin in African Americans: the Jackson Heart Study.
Bidulescu A, Liu J, Hickson DA, Hairston KG, Fox ER, Arnett DK, Sumner AE, Taylor HA, Gibbons GH. Bidulescu A, et al. BMC Cardiovasc Disord. 2013 Feb 22;13:9. doi: 10.1186/1471-2261-13-9. BMC Cardiovasc Disord. 2013. PMID: 23433085 Free PMC article. - Visceral adiposity and inflammatory bowel disease.
Rowan CR, McManus J, Boland K, O'Toole A. Rowan CR, et al. Int J Colorectal Dis. 2021 Nov;36(11):2305-2319. doi: 10.1007/s00384-021-03968-w. Epub 2021 Jun 9. Int J Colorectal Dis. 2021. PMID: 34104989 Review. - Ethnic and sex differences in body fat and visceral and subcutaneous adiposity in children and adolescents.
Staiano AE, Katzmarzyk PT. Staiano AE, et al. Int J Obes (Lond). 2012 Oct;36(10):1261-9. doi: 10.1038/ijo.2012.95. Epub 2012 Jun 19. Int J Obes (Lond). 2012. PMID: 22710928 Free PMC article. Review.
Cited by
- Associations between accurate measures of adiposity and fitness, blood proteins, and insulin sensitivity among South Asians and Europeans.
Kho PF, Stell L, Jimenez S, Zanetti D, Panyard DJ, Watson KL, Sarraju A, Chen ML, Lind L, Petrie JR, Chan KN, Fonda H, Kent K, Myers JN, Palaniappan L, Abbasi F, Assimes TL. Kho PF, et al. medRxiv [Preprint]. 2024 Sep 7:2024.09.06.24313199. doi: 10.1101/2024.09.06.24313199. medRxiv. 2024. PMID: 39281745 Free PMC article. Preprint. - Association Between Visceral Obesity and Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Retrospective Study.
Shang C, Yuan M, Wang Y, Wang Y, Bao W, Zeng S, Zhang D, Liu P, Sun L. Shang C, et al. Diabetes Metab Syndr Obes. 2024 Jul 31;17:2869-2880. doi: 10.2147/DMSO.S470836. eCollection 2024. Diabetes Metab Syndr Obes. 2024. PMID: 39100969 Free PMC article. - Adiponectin and TNFα in relation to glucometabolic control in patients with type 2 diabetes mellitus.
Habib SS, Al-Khlaiwi T, Al-Khliwi H, Habib SM, Habib SA, Habib SH, Khan A. Habib SS, et al. J Family Med Prim Care. 2024 Jul;13(7):2741-2745. doi: 10.4103/jfmpc.jfmpc_1896_23. Epub 2024 Jun 28. J Family Med Prim Care. 2024. PMID: 39070992 Free PMC article. - The subcutaneous adipose transcriptome identifies a molecular signature of insulin resistance shared with visceral adipose.
Mashayekhi M, Sheng Q, Bailin SS, Massier L, Zhong J, Shi M, Wanjalla CN, Wang TJ, Ikizler TA, Niswender KD, Gabriel CL, Palacios J, Turgeon-Jones R, Reynolds CF, Luther JM, Brown NJ, Das S, Dahlman I, Mosley JD, Koethe JR, Rydén M, Bachmann KN, Shah RV. Mashayekhi M, et al. Obesity (Silver Spring). 2024 Aug;32(8):1526-1540. doi: 10.1002/oby.24064. Epub 2024 Jul 5. Obesity (Silver Spring). 2024. PMID: 38967296 - Visceral Fat Area and Subcutaneous Fat Area Increase in Hyperthyroidism Patients After Treatment-A Single-Group Repeated-Measures Trial.
Li M, Yang X, Li R, Wu B, Hao J, Qi Y, Bai T, Yang L, Zhang Y, Liu Y. Li M, et al. Diabetes Metab Syndr Obes. 2024 May 27;17:2165-2176. doi: 10.2147/DMSO.S458486. eCollection 2024. Diabetes Metab Syndr Obes. 2024. PMID: 38827164 Free PMC article.
References
- Bonora E, Kiechl S, Willeit J, et al. Insulin resistance as estimated by homeostasis model assessment predicts incident symptomatic cardiovascular disease in caucasian subjects from the general population: the Bruneck study. Diabetes Care. 2007;30:318–324. - PubMed
- Fujimoto WY. The importance of insulin resistance in the pathogenesis of type 2 diabetes mellitus. Am J Med. 2000;108(Suppl 6a):9S–14S. - PubMed
- Jeppesen J, Hansen TW, Rasmussen S, et al. Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease: a population-based study. J Am Coll Cardiol. 2007;49:2112–2119. - PubMed
- McLaughlin T, Allison G, Abbasi F, Lamendola C, Reaven G. Prevalence of insulin resistance and associated cardiovascular disease risk factors among normal weight, overweight, and obese individuals. Metab Clin Exp. 2004;53:495–499. - PubMed
- Després JP, Lemieux I, Bergeron J, et al. Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol. 2008;28:1039–1049. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
- N01-HC-25195/HC/NHLBI NIH HHS/United States
- N01 HC025195/HC/NHLBI NIH HHS/United States
- K24 DK080140/DK/NIDDK NIH HHS/United States
- R01DK080739/DK/NIDDK NIH HHS/United States
- R01 DK080739/DK/NIDDK NIH HHS/United States
- N01HC25195/HL/NHLBI NIH HHS/United States
- Z99 HL999999/ImNIH/Intramural NIH HHS/United States
LinkOut - more resources
Full Text Sources
Medical
Research Materials