Glycosylation products as toxic mediators of diabetic complications - PubMed (original) (raw)

Review

Glycosylation products as toxic mediators of diabetic complications

M Brownlee. Annu Rev Med. 1991.

Abstract

Hyperglycemia causes excessive amounts of irreversible advanced glycosylation end products (AGEPs) to accumulate on long-lived extracellular matrix proteins and probably also on DNA in tissues that develop diabetic complications. AGEPs induce permanent abnormalities in extracellular protein cross-linking, cell-matrix interactions, and DNA structure in vitro. Pharmacologically inhibiting AGEP formation in long-term diabetic animals prevents both retinal capillary pathology and thickening of the glomerular basement membrane.

PubMed Disclaimer

Similar articles

• Hyperglycemia and microangiopathy. Direct regulation by glucose of microvascular cells.
  Kreisberg JI. Kreisberg JI. Lab Invest. 1992 Oct;67(4):416-26. Lab Invest. 1992. PMID: 1434526 Review. No abstract available.
• Significant glomerular basement membrane thickening in hyperglycemic and normoglycemic diabetic-prone BB Wistar rats.
  Carlson EC, Vari RC, Audette JL, Finke MA, Ressler MJ. Carlson EC, et al. Anat Rec A Discov Mol Cell Evol Biol. 2004 Dec;281(2):1308-18. doi: 10.1002/ar.a.20136. Anat Rec A Discov Mol Cell Evol Biol. 2004. PMID: 15532046
• The pathological implications of protein glycation.
  Brownlee M. Brownlee M. Clin Invest Med. 1995 Aug;18(4):275-81. Clin Invest Med. 1995. PMID: 8549013 Review.
• Advanced glycosylated end products and hyperglycemia in the pathogenesis of diabetic complications.
  Friedman EA. Friedman EA. Diabetes Care. 1999 Mar;22 Suppl 2:B65-71. Diabetes Care. 1999. PMID: 10097902 Review.
• Microvascular basement membranes in diabetes mellitus.
  Tsilibary EC. Tsilibary EC. J Pathol. 2003 Jul;200(4):537-46. doi: 10.1002/path.1439. J Pathol. 2003. PMID: 12845621 Review.

Cited by

• The molecular basis of Human FN3K mediated phosphorylation of glycated substrate.
  Garg A, On KF, Xiao Y, Elkayam E, Cifani P, David Y, Joshua-Tor L. Garg A, et al. bioRxiv [Preprint]. 2024 Aug 5:2024.08.05.606604. doi: 10.1101/2024.08.05.606604. bioRxiv. 2024. PMID: 39149269 Free PMC article. Preprint.
• Central Role of β-1,4-GalT-V in Cancer Signaling, Inflammation, and Other Disease-Centric Pathways.
  Chatterjee S, Yuan R, Thapa S, Talwar R. Chatterjee S, et al. Int J Mol Sci. 2023 Dec 29;25(1):483. doi: 10.3390/ijms25010483. Int J Mol Sci. 2023. PMID: 38203654 Free PMC article. Review.
• Impact of Dietary Advanced Glycation End Products on Female Reproduction: Review of Potential Mechanistic Pathways.
  Mouanness M, Merhi Z. Mouanness M, et al. Nutrients. 2022 Feb 24;14(5):966. doi: 10.3390/nu14050966. Nutrients. 2022. PMID: 35267940 Free PMC article. Review.
• Mice with Type 2 Diabetes Present Significant Alterations in Their Tissue Biomechanical Properties and Histological Features.
  Cruz TB, Carvalho FA, Matafome PN, Soares RA, Santos NC, Travasso RD, Oliveira MJ. Cruz TB, et al. Biomedicines. 2021 Dec 28;10(1):57. doi: 10.3390/biomedicines10010057. Biomedicines. 2021. PMID: 35052737 Free PMC article.
• Comprehensive overview of human serum albumin glycation in diabetes mellitus.
  Qiu HY, Hou NN, Shi JF, Liu YP, Kan CX, Han F, Sun XD. Qiu HY, et al. World J Diabetes. 2021 Jul 15;12(7):1057-1069. doi: 10.4239/wjd.v12.i7.1057. World J Diabetes. 2021. PMID: 34326954 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ingenta plc

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information