Characterization of the protective antibody response to Borrelia burgdorferi in experimentally infected LSH hamsters - PubMed (original) (raw)

Characterization of the protective antibody response to Borrelia burgdorferi in experimentally infected LSH hamsters

J L Schmitz et al. Infect Immun. 1991 Jun.

Abstract

We show that serum obtained from normal hamsters infected with Borrelia burgdorferi can confer complete protection on irradiated recipients challenged with the Lyme spirochete. Borreliacidal activity was detected 7 days after infection, peaked at weeks 3 to 5, and thereafter decreased. Relatively high borreliacidal activity was detected in immune serum at weeks 3 and 5 of infection. The borreliacidal activity did not correlate with antibody used for the serodiagnosis of Lyme disease, which remained elevated throughout experimental infection. Our results also demonstrated that blocking antibody and antigenic variation in B. burgdorferi did not account for the decreasing titer of protective antibody. These findings indicate that protection against reinfection gradually wanes.

PubMed Disclaimer

References

1. 1. J Immunol. 1968 Mar;100(3):507-15 -PubMed
2. 1. Science. 1990 Oct 26;250(4980):553-6 -PubMed
3. 1. Nature. 1970 Aug 15;227(5259):680-5 -PubMed
4. 1. J Immunol. 1971 Jul;107(1):76-82 -PubMed
5. 1. J Immunol. 1975 Sep;115(3):693-700 -PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PMC
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information