Intake of carbohydrates compared with intake of saturated fatty acids and risk of myocardial infarction: importance of the glycemic index - PubMed (original) (raw)
doi: 10.3945/ajcn.2009.29099. Epub 2010 Apr 7.
Affiliations
- PMID: 20375186
- DOI: 10.3945/ajcn.2009.29099
Free article
Intake of carbohydrates compared with intake of saturated fatty acids and risk of myocardial infarction: importance of the glycemic index
Marianne U Jakobsen et al. Am J Clin Nutr. 2010 Jun.
Free article
Abstract
Background: Studies have suggested that replacing saturated fatty acids (SFAs) with carbohydrates is modestly associated with a higher risk of ischemic heart disease, whereas replacing SFAs with polyunsaturated fatty acids is associated with a lower risk of ischemic heart disease. The effect of carbohydrates, however, may depend on the type consumed.
Objectives: By using substitution models, we aimed to investigate the risk of myocardial infarction (MI) associated with a higher energy intake from carbohydrates and a concomitant lower energy intake from SFAs. Carbohydrates with different glycemic index (GI) values were also investigated.
Design: Our prospective cohort study included 53,644 women and men free of MI at baseline.
Results: During a median of 12 y of follow-up, 1943 incident MI cases occurred. There was a nonsignificant inverse association between substitution of carbohydrates with low-GI values for SFAs and risk of MI [hazard ratio (HR) for MI per 5% increment of energy intake from carbohydrates: 0.88; 95% CI: 0.72, 1.07). In contrast, there was a statistically significant positive association between substitution of carbohydrates with high-GI values for SFAs and risk of MI (HR: 1.33; 95% CI: 1.08, 1.64). There was no association for carbohydrates with medium-GI values (HR: 0.98; 95% CI: 0.80, 1.21). No effect modification by sex was observed.
Conclusion: This study suggests that replacing SFAs with carbohydrates with low-GI values is associated with a lower risk of MI, whereas replacing SFAs with carbohydrates with high-GI values is associated with a higher risk of MI.
Comment in
- Are refined carbohydrates worse than saturated fat?
Hu FB. Hu FB. Am J Clin Nutr. 2010 Jun;91(6):1541-2. doi: 10.3945/ajcn.2010.29622. Epub 2010 Apr 21. Am J Clin Nutr. 2010. PMID: 20410095 Free PMC article. No abstract available.
Similar articles
- Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies.
Jakobsen MU, O'Reilly EJ, Heitmann BL, Pereira MA, Bälter K, Fraser GE, Goldbourt U, Hallmans G, Knekt P, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Ascherio A. Jakobsen MU, et al. Am J Clin Nutr. 2009 May;89(5):1425-32. doi: 10.3945/ajcn.2008.27124. Epub 2009 Feb 11. Am J Clin Nutr. 2009. PMID: 19211817 Free PMC article. - Dietary fatty acid intake after myocardial infarction: a theoretical substitution analysis of the Alpha Omega Cohort.
Mölenberg FJM, de Goede J, Wanders AJ, Zock PL, Kromhout D, Geleijnse JM. Mölenberg FJM, et al. Am J Clin Nutr. 2017 Sep 1;106(3):895-901. doi: 10.3945/ajcn.117.157826. Am J Clin Nutr. 2017. PMID: 28793994 Free PMC article. - Consumption of individual saturated fatty acids and the risk of myocardial infarction in a UK and a Danish cohort.
Praagman J, Vissers LET, Mulligan AA, Laursen ASD, Beulens JWJ, van der Schouw YT, Wareham NJ, Hansen CP, Khaw KT, Jakobsen MU, Sluijs I. Praagman J, et al. Int J Cardiol. 2019 Mar 15;279:18-26. doi: 10.1016/j.ijcard.2018.10.064. Epub 2018 Oct 22. Int J Cardiol. 2019. PMID: 30482628 Free PMC article. - Reduction in saturated fat intake for cardiovascular disease.
Hooper L, Martin N, Abdelhamid A, Davey Smith G. Hooper L, et al. Cochrane Database Syst Rev. 2015 Jun 10;(6):CD011737. doi: 10.1002/14651858.CD011737. Cochrane Database Syst Rev. 2015. PMID: 26068959 Updated. Review. - The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010?
Astrup A, Dyerberg J, Elwood P, Hermansen K, Hu FB, Jakobsen MU, Kok FJ, Krauss RM, Lecerf JM, LeGrand P, Nestel P, Risérus U, Sanders T, Sinclair A, Stender S, Tholstrup T, Willett WC. Astrup A, et al. Am J Clin Nutr. 2011 Apr;93(4):684-8. doi: 10.3945/ajcn.110.004622. Epub 2011 Jan 26. Am J Clin Nutr. 2011. PMID: 21270379 Free PMC article. Review.
Cited by
- Efficacy of tryushnadya churna in metabolic syndrome with obesity - A randomized double blind controlled clinical trial.
Chandake S, Tubaki BR, Gonugade V, Sharma O. Chandake S, et al. J Ayurveda Integr Med. 2024 Jul-Aug;15(4):100973. doi: 10.1016/j.jaim.2024.100973. Epub 2024 Aug 10. J Ayurveda Integr Med. 2024. PMID: 39128430 Free PMC article. - Association Between Nutrients and Cardiovascular Diseases.
Shakarami A. Shakarami A. Curr Cardiol Rev. 2024 Jan 5;20(1):E050124225283. doi: 10.2174/011573403X263414231101095310. Online ahead of print. Curr Cardiol Rev. 2024. PMID: 38185894 - Influence of dietary pattern on anti-tuberculosis treatment outcomes in persons with dysglycemia: a Peruvian prospective cohort study.
Arriaga MB, Araújo-Pereira M, Andrade VMB, Queiroz ATL, Fernandes CD, Sales C, Aliaga JG, Shivakoti R, Lecca L, Calderon RI, Andrade BB. Arriaga MB, et al. Front Nutr. 2023 Dec 18;10:1254983. doi: 10.3389/fnut.2023.1254983. eCollection 2023. Front Nutr. 2023. PMID: 38164414 Free PMC article. - Substitution of animal-based with plant-based foods on cardiometabolic health and all-cause mortality: a systematic review and meta-analysis of prospective studies.
Neuenschwander M, Stadelmaier J, Eble J, Grummich K, Szczerba E, Kiesswetter E, Schlesinger S, Schwingshackl L. Neuenschwander M, et al. BMC Med. 2023 Nov 16;21(1):404. doi: 10.1186/s12916-023-03093-1. BMC Med. 2023. PMID: 37968628 Free PMC article. - Evidence-based European recommendations for the dietary management of diabetes.
Diabetes and Nutrition Study Group (DNSG) of the European Association for the Study of Diabetes (EASD). Diabetes and Nutrition Study Group (DNSG) of the European Association for the Study of Diabetes (EASD). Diabetologia. 2023 Jun;66(6):965-985. doi: 10.1007/s00125-023-05894-8. Diabetologia. 2023. PMID: 37069434
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical