Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells - PubMed (original) (raw)
Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells
Anna Fialová et al. Microbes Infect. 2010 Jul.
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Abstract
Tick-borne encephalitis virus is an important human pathogen, naturally delivered into host skin via a tick bite. To examine the effects of the virus on dendritic cell biology, we cultured dendritic cells with two tick-borne encephalitis virus strains of different virulence in the presence of Ixodes ricinus tick saliva. Tick saliva treatment increased proportion of virus-infected cells, led to a decrease in virus-induced TNF-alpha and IL-6 production and to reduced virus-induced apoptosis. Our data indicate that tick saliva modulate virus-mediated alterations in dendritic cells, thus probably being involved in the early infection process in the host.