The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors - PubMed (original) (raw)

Review

doi: 10.1038/ni.1863. Epub 2010 Apr 20.

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• PMID: 20404851
• DOI: 10.1038/ni.1863

Review

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Taro Kawai et al. Nat Immunol. 2010 May.

Abstract

The discovery of Toll-like receptors (TLRs) as components that recognize conserved structures in pathogens has greatly advanced understanding of how the body senses pathogen invasion, triggers innate immune responses and primes antigen-specific adaptive immunity. Although TLRs are critical for host defense, it has become apparent that loss of negative regulation of TLR signaling, as well as recognition of self molecules by TLRs, are strongly associated with the pathogenesis of inflammatory and autoimmune diseases. Furthermore, it is now clear that the interaction between TLRs and recently identified cytosolic innate immune sensors is crucial for mounting effective immune responses. Here we describe the recent advances that have been made by research into the role of TLR biology in host defense and disease.

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