A novel secreted cyclophilin-like protein (SCYLP) - PubMed (original) (raw)
Comparative Study
. 1991 Jun 15;266(17):10735-8.
Affiliations
- PMID: 2040592
Free article
Comparative Study
A novel secreted cyclophilin-like protein (SCYLP)
G Spik et al. J Biol Chem. 1991.
Free article
Abstract
A novel cyclosporin A binding glycoprotein of 21 kDa was isolated from human milk by several steps of cation exchange chromatography. The corresponding gene was cloned from human T cells, expressed in Escherichia coli and the recombinant protein purified. The protein shares 58% amino acid identity with the cytosolic cyclophilin and is initially synthesized with a hydrophobic leader sequence. The cyclophilin-like protein has also peptidyl-prolyl cis/trans-isomerase activity, although less efficient, that is inhibited by cyclosporin A. The existence of a secreted form of cyclophilin-like protein in addition to the previously known cytosolic cyclophilin implies that these proteins act on different in vivo targets.
Similar articles
- Structure and expression of cytosolic cyclophilin/peptidyl-prolyl cis-trans isomerase of higher plants and production of active tomato cyclophilin in Escherichia coli.
Gasser CS, Gunning DA, Budelier KA, Brown SM. Gasser CS, et al. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9519-23. doi: 10.1073/pnas.87.24.9519. Proc Natl Acad Sci U S A. 1990. PMID: 1702215 Free PMC article. - An endoplasmic reticulum-specific cyclophilin.
Hasel KW, Glass JR, Godbout M, Sutcliffe JG. Hasel KW, et al. Mol Cell Biol. 1991 Jul;11(7):3484-91. doi: 10.1128/mcb.11.7.3484-3491.1991. Mol Cell Biol. 1991. PMID: 1710767 Free PMC article. - Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.
Price ER, Zydowsky LD, Jin MJ, Baker CH, McKeon FD, Walsh CT. Price ER, et al. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1903-7. doi: 10.1073/pnas.88.5.1903. Proc Natl Acad Sci U S A. 1991. PMID: 2000394 Free PMC article. - Structural and functional features of the peptidyl prolyl cis-trans isomerase, cyclophilin.
Harding MW. Harding MW. Pharmacotherapy. 1991;11(6):142S-148S. Pharmacotherapy. 1991. PMID: 1771139 Review. No abstract available. - Peptidyl-prolyl cis-trans isomerases, cyclophilin, FK506-binding protein, and ninaA: four of a kind.
Stamnes MA, Zuker CS. Stamnes MA, et al. Curr Opin Cell Biol. 1990 Dec;2(6):1104-7. doi: 10.1016/0955-0674(90)90163-9. Curr Opin Cell Biol. 1990. PMID: 2099804 Review. No abstract available.
Cited by
- Octasaccharide is the minimal length unit required for efficient binding of cyclophilin B to heparin and cell surface heparan sulphate.
Vanpouille C, Denys A, Carpentier M, Pakula R, Mazurier J, Allain F. Vanpouille C, et al. Biochem J. 2004 Sep 1;382(Pt 2):733-40. doi: 10.1042/BJ20031453. Biochem J. 2004. PMID: 15109301 Free PMC article. - Elevated serum cyclophilin levels in patients with severe sepsis.
Tegeder I, Schumacher A, John S, Geiger H, Geisslinger G, Bang H, Brune K. Tegeder I, et al. J Clin Immunol. 1997 Sep;17(5):380-6. doi: 10.1023/a:1027364207544. J Clin Immunol. 1997. PMID: 9327337 - A yeast cyclophilin gene essential for lactate metabolism at high temperature.
Davis ES, Becker A, Heitman J, Hall MN, Brennan MB. Davis ES, et al. Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11169-73. doi: 10.1073/pnas.89.23.11169. Proc Natl Acad Sci U S A. 1992. PMID: 1454795 Free PMC article. - Cyclophilins and cyclophilin inhibitors in nidovirus replication.
de Wilde AH, Pham U, Posthuma CC, Snijder EJ. de Wilde AH, et al. Virology. 2018 Sep;522:46-55. doi: 10.1016/j.virol.2018.06.011. Epub 2018 Jul 12. Virology. 2018. PMID: 30014857 Free PMC article. Review. - Interaction with glycosaminoglycans is required for cyclophilin B to trigger integrin-mediated adhesion of peripheral blood T lymphocytes to extracellular matrix.
Allain F, Vanpouille C, Carpentier M, Slomianny MC, Durieux S, Spik G. Allain F, et al. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2714-9. doi: 10.1073/pnas.052284899. Epub 2002 Feb 26. Proc Natl Acad Sci U S A. 2002. PMID: 11867726 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases