Intestinal fermentation modulates postprandial acylcarnitine profile and nitrogen metabolism in a true carnivore: the domestic cat ( Felis catus) - PubMed (original) (raw)

Intestinal fermentation modulates postprandial acylcarnitine profile and nitrogen metabolism in a true carnivore: the domestic cat ( Felis catus)

Adronie Verbrugghe et al. Br J Nutr. 2010 Oct.

Abstract

N balance and postprandial acylcarnitine profile following intestinal fermentation of oligofructose and inulin were investigated in healthy cats. Two diets were tested in a crossover design: a commercial high-protein cat food supplemented with 4 % DM oligofructose and inulin (spectrum: degree of polymerisation (DP) 2-10: 60 (SE 5) % DM; DP>10: 28 (SE 5) % DM) as high-fermentable fibre (HFF) diet, and the same commercial diet supplemented with 4 % DM cellulose as low-fermentable fibre diet. Eight adult cats were randomly allotted to each of the two diets at intervals of 4 weeks. At the end of each testing period, faeces and urine were collected over a 5-d period, and blood samples were obtained before and at the selected time points postprandially. No differences were found for N intake, N digestibility and faecal N excretion, whereas urinary N excretion was lower when the HFF diet was fed (P = 0.044). N balance was positive in all the cats, and tended to be increased when the HFF diet was fed (P = 0.079). Propionylcarnitine concentrations (P = 0.015) and their area under the curve (AUC) (P = 0.013) were increased when the HFF diet was fed, revealing a more pronounced production and absorption of propionate. Yet, methylmalonylcarnitine concentrations and concurrent AUC were not elevated when the HFF diet was fed, indicating reduced amino acid catabolism. 3-Hydroxy-3-methylglutarylcarnitine concentrations (P = 0.026) and their AUC (P = 0.028) were also reduced when the HFF diet was fed, implying diminished use of branched-chain amino acids as well. In healthy cats, oligofructose and inulin added to a high-protein diet were suggested to reduce postprandial amino acid-induced gluconeogenesis by substitution with propionate.

PubMed Disclaimer

Cited by

Chronic kidney disease in cats alters response of the plasma metabolome and fecal microbiome to dietary fiber.
Hall JA, Jackson MI, Jewell DE, Ephraim E. Hall JA, et al. PLoS One. 2020 Jul 2;15(7):e0235480. doi: 10.1371/journal.pone.0235480. eCollection 2020. PLoS One. 2020. PMID: 32614877 Free PMC article.
Carbohydrate level and source have minimal effects on feline energy and macronutrient metabolism.
Asaro NJ, Berendt KD, Zijlstra RT, Brewer J, Shoveller AK. Asaro NJ, et al. J Anim Sci. 2018 Dec 3;96(12):5052-5063. doi: 10.1093/jas/sky365. J Anim Sci. 2018. PMID: 30219852 Free PMC article.
The response of canine faecal microbiota to increased dietary protein is influenced by body condition.
Xu J, Verbrugghe A, Lourenço M, Cools A, Liu DJX, Van de Wiele T, Marzorati M, Eeckhaut V, Van Immerseel F, Vanhaecke L, Campos M, Hesta M. Xu J, et al. BMC Vet Res. 2017 Dec 4;13(1):374. doi: 10.1186/s12917-017-1276-0. BMC Vet Res. 2017. PMID: 29202841 Free PMC article.
Fermentable soluble fibres spare amino acids in healthy dogs fed a low-protein diet.
Wambacq W, Rybachuk G, Jeusette I, Rochus K, Wuyts B, Fievez V, Nguyen P, Hesta M. Wambacq W, et al. BMC Vet Res. 2016 Jun 28;12(1):130. doi: 10.1186/s12917-016-0752-2. BMC Vet Res. 2016. PMID: 27353524 Free PMC article.
Faecal microbiota of domestic cats fed raw whole chicks v. an extruded chicken-based diet.
Kerr KR, Dowd SE, Swanson KS. Kerr KR, et al. J Nutr Sci. 2014 Sep 25;3:e22. doi: 10.1017/jns.2014.21. eCollection 2014. J Nutr Sci. 2014. PMID: 26101591 Free PMC article.

Intestinal fermentation modulates postprandial acylcarnitine profile and nitrogen metabolism in a true carnivore: the domestic cat ( Felis catus) - PubMed (original) (raw)