Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques - PubMed (original) (raw)

Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques

Porntip Chaichompoo et al. Cell Immunol. 2010.

Abstract

Innate immune mechanisms play a deterministic role in the rate of disease progression during acute infection in HIV infected humans and SIV infection of non-human primates. The role NK cells play in mediating such an effect has thus gained importance. One of the major sets of molecules that regulate NK cell function are the killer cell immunoglobulin-like molecules (KIR's). Our laboratory has previously shown an association of KIR3DL alleles 13 and 14 with high plasma viral loads in a cohort of SIV-infected rhesus macaques. To gain a more detailed understanding of the role of KIR polymorphisms, our laboratory herein conducted studies of three additional KIR loci and show that select KIR3DH alleles appear to be more strongly associated with high plasma viral loads than KIR3DL alleles 13 and 14. In addition, we herein document the existence of additional new alleles for the KIR1D, KIR2DL4, and the KIR3DH loci.

Copyright (c) 2010 Elsevier Inc. All rights reserved.

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Figures

FIGURE 1

FIGURE 1

Phylogenetic tree of the Mamu-KIR2DL4 extracellular domain at the protein level

FIGURE 2

FIGURE 2

The predicted Mamu-KIR2DL4 intra- and extra-cellular domains

FIGURE 3

FIGURE 3

Phylogenetic tree of the Mamu-KIR1D locus at the protein level

FIGURE 4

FIGURE 4

Cluster I and II alleles at the protein level comprising the Mamu-KIR1D alleles (the solid black lines reflect the ITIM's)

FIGURE 4

FIGURE 4

Cluster I and II alleles at the protein level comprising the Mamu-KIR1D alleles (the solid black lines reflect the ITIM's)

FIGURE 5

FIGURE 5

Phylogenetic tree of the Mamu-KIR3DH extracellular domain at the protein level *Mamu-KIR3DH allele-1 and 2 have been described previously

Figure 6

Figure 6

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