The multiple roles of monocyte subsets in steady state and inflammation - PubMed (original) (raw)

Review

The multiple roles of monocyte subsets in steady state and inflammation

Clinton S Robbins et al. Cell Mol Life Sci. 2010 Aug.

Abstract

Monocytes participate importantly in immunity. Produced in the bone marrow and released into the blood, they circulate in blood or reside in a spleen reservoir before entering tissue and giving rise to macrophages or dendritic cells. Monocytes are more than transitional cells that adapt to a particular tissue environment indiscriminately. Accumulating evidence now indicates that monocytes are heterogeneous in several species and are themselves predetermined for particular function in the steady state and inflammation. Future therapeutics may harness this heterogeneity to target harmful functions while sparing those that are beneficial. Here, we review recent advances on the ontogeny and function of monocytes and their subsets in humans and mice.

PubMed Disclaimer

Figures

Fig. 1

The development, phenotype, differentiation, and distribution of mouse monocyte subsets and allied myeloid cells. Cartoon depicts the development of monocyte subsets in the bone marrow, their entrance into the blood and accumulation in tissue. Brown arrows depict migration and black arrows depict differentiation. Markers listed in brown depict molecules by which movement is mediated. Ly-6C high Ly-6Chigh monocyte, Ly-6C low Ly-6Clow monocyte, GMP granulocyte and macrophage progenitor, MDP macrophage and dendritic cell progenitor, CDP common dendritic cell progenitor, preDC pre-dendritic cell, TipDC TNFα and iNOS-producing dendritic cell, Mϕ macrophage

Similar articles

• Migratory fate and differentiation of blood monocyte subsets.
  Tacke F, Randolph GJ. Tacke F, et al. Immunobiology. 2006;211(6-8):609-18. doi: 10.1016/j.imbio.2006.05.025. Epub 2006 Jul 10. Immunobiology. 2006. PMID: 16920499 Review.
• Monocyte trafficking in acute and chronic inflammation.
  Ingersoll MA, Platt AM, Potteaux S, Randolph GJ. Ingersoll MA, et al. Trends Immunol. 2011 Oct;32(10):470-7. doi: 10.1016/j.it.2011.05.001. Epub 2011 Jun 12. Trends Immunol. 2011. PMID: 21664185 Free PMC article. Review.
• Monocyte and macrophage heterogeneity.
  Gordon S, Taylor PR. Gordon S, et al. Nat Rev Immunol. 2005 Dec;5(12):953-64. doi: 10.1038/nri1733. Nat Rev Immunol. 2005. PMID: 16322748 Review.
• Monocyte homeostasis and the plasticity of inflammatory monocytes.
  Mitchell AJ, Roediger B, Weninger W. Mitchell AJ, et al. Cell Immunol. 2014 Sep-Oct;291(1-2):22-31. doi: 10.1016/j.cellimm.2014.05.010. Epub 2014 Jun 11. Cell Immunol. 2014. PMID: 24962351 Review.
• Monocytes: subsets, origins, fates and functions.
  Yona S, Jung S. Yona S, et al. Curr Opin Hematol. 2010 Jan;17(1):53-9. doi: 10.1097/MOH.0b013e3283324f80. Curr Opin Hematol. 2010. PMID: 19770654 Review.

Cited by

• High-density lipoprotein mimetic nano-therapeutics targeting monocytes and macrophages for improved cardiovascular care: a comprehensive review.
  Zhen J, Li X, Yu H, Du B. Zhen J, et al. J Nanobiotechnology. 2024 May 17;22(1):263. doi: 10.1186/s12951-024-02529-x. J Nanobiotechnology. 2024. PMID: 38760755 Free PMC article. Review.
• Intravital imaging of splenic classical monocytes modifying the hepatic CX3CR1+ cells motility to exacerbate liver fibrosis via spleen-liver axis.
  Han C, Zhai Y, Wang Y, Peng X, Zhang X, Dai B, Leng Y, Zhang Z, Qi S. Han C, et al. Theranostics. 2024 Mar 3;14(5):2210-2231. doi: 10.7150/thno.87791. eCollection 2024. Theranostics. 2024. PMID: 38505603 Free PMC article.
• Prognostic Value of the Baseline and Early Changes in Monocyte-to-Lymphocyte Ratio for Short-Term Mortality among Critically Ill Patients with Acute Kidney Injury.
  Luo X, Wan D, Xia R, Liao R, Su B. Luo X, et al. J Clin Med. 2023 Nov 28;12(23):7353. doi: 10.3390/jcm12237353. J Clin Med. 2023. PMID: 38068405 Free PMC article.
• Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection.
  Lin J, Moradi E, Salenius K, Lehtipuro S, Häkkinen T, Laiho JE, Oikarinen S, Randelin S, Parikh HM, Krischer JP, Toppari J, Lernmark Å, Petrosino JF, Ajami NJ, She JX, Hagopian WA, Rewers MJ, Lloyd RE, Rautajoki KJ, Hyöty H, Nykter M; TEDDY Study Group. Lin J, et al. Nat Commun. 2023 Nov 22;14(1):7630. doi: 10.1038/s41467-023-42763-9. Nat Commun. 2023. PMID: 37993433 Free PMC article.
• Decoding the immune landscape following hip fracture in elderly patients: unveiling temporal dynamics through single-cell RNA sequencing.
  Lu Y, Luo Y, Zhang Q, Chen W, Zhang N, Wang L, Zhang Y. Lu Y, et al. Immun Ageing. 2023 Oct 17;20(1):54. doi: 10.1186/s12979-023-00380-6. Immun Ageing. 2023. PMID: 37848979 Free PMC article.

References

1. 1. Auffray C, Sieweke MH, Geissmann F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol. 2009;27:669–692. doi: 10.1146/annurev.immunol.021908.132557. - DOI - PubMed
2. 1. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005;5:953–964. doi: 10.1038/nri1733. - DOI - PubMed
3. 1. Sabin FR, Doan CA. The relation of monocytes and clasmatocytes to early infection in rabbits with bovine Tubercle Bacilli. J Exp Med. 1927;46:627–644. doi: 10.1084/jem.46.4.627. - DOI - PMC - PubMed
4. 1. van Furth R, Cohn ZA. The origin and kinetics of mononuclear phagocytes. J Exp Med. 1968;128:415–435. doi: 10.1084/jem.128.3.415. - DOI - PMC - PubMed
5. 1. Yasaka T, Mantich NM, Boxer LA, Baehner RL. Functions of human monocyte and lymphocyte subsets obtained by countercurrent centrifugal elutriation: differing functional capacities of human monocyte subsets. J Immunol. 1981;127:1515–1518. - PubMed

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central
  • Springer