Neurons derive from the more apical daughter in asymmetric divisions in the zebrafish neural tube - PubMed (original) (raw)

doi: 10.1038/nn.2547. Epub 2010 May 9.

Affiliations

• PMID: 20453852
• DOI: 10.1038/nn.2547

Neurons derive from the more apical daughter in asymmetric divisions in the zebrafish neural tube

Paula Alexandre et al. Nat Neurosci. 2010 Jun.

Abstract

In the developing CNS, asymmetric cell division is critical for maintaining the balanced production of differentiating neurons while renewing the population of neural progenitors. In invertebrates, this process depends on asymmetric inheritance of fate determinants during progenitor divisions. A similar mechanism is widely believed to underlie asymmetrically fated divisions in vertebrates, but compelling evidence for this is missing. We used live imaging of individual progenitors in the intact zebrafish embryo CNS to test this hypothesis. We found that asymmetric inheritance of a subcellular domain is strongly correlated with asymmetric daughter fates and our results reveal an unexpected feature of this process. The daughter cell destined to become a neuron was derived from the more apical of the two daughters, whereas the more basal daughter inherited the basal process and replenished the apical progenitor pool.

PubMed Disclaimer

Similar articles

• Oblique radial glial divisions in the developing mouse neocortex induce self-renewing progenitors outside the germinal zone that resemble primate outer subventricular zone progenitors.
  Shitamukai A, Konno D, Matsuzaki F. Shitamukai A, et al. J Neurosci. 2011 Mar 9;31(10):3683-95. doi: 10.1523/JNEUROSCI.4773-10.2011. J Neurosci. 2011. PMID: 21389223 Free PMC article.
• Asymmetric inheritance of the apical domain and self-renewal of retinal ganglion cell progenitors depend on Anillin function.
  Paolini A, Duchemin AL, Albadri S, Patzel E, Bornhorst D, González Avalos P, Lemke S, Machate A, Brand M, Sel S, Di Donato V, Del Bene F, Zolessi FR, Ramialison M, Poggi L. Paolini A, et al. Development. 2015 Mar 1;142(5):832-9. doi: 10.1242/dev.118612. Epub 2015 Feb 5. Development. 2015. PMID: 25655700
• Monitoring neural progenitor fate through multiple rounds of division in an intact vertebrate brain.
  Lyons DA, Guy AT, Clarke JD. Lyons DA, et al. Development. 2003 Aug;130(15):3427-36. doi: 10.1242/dev.00569. Development. 2003. PMID: 12810590
• Role of polarized cell divisions in zebrafish neural tube formation.
  Clarke J. Clarke J. Curr Opin Neurobiol. 2009 Apr;19(2):134-8. doi: 10.1016/j.conb.2009.04.010. Epub 2009 May 15. Curr Opin Neurobiol. 2009. PMID: 19447605 Free PMC article. Review.
• Timing cell-fate determination during asymmetric cell divisions.
  Zhong W. Zhong W. Curr Opin Neurobiol. 2008 Oct;18(5):472-8. doi: 10.1016/j.conb.2008.10.005. Epub 2008 Nov 12. Curr Opin Neurobiol. 2008. PMID: 18983918 Free PMC article. Review.

Cited by

• Indirect neurogenesis in space and time.
  Thor S. Thor S. Nat Rev Neurosci. 2024 Aug;25(8):519-534. doi: 10.1038/s41583-024-00833-x. Epub 2024 Jul 1. Nat Rev Neurosci. 2024. PMID: 38951687 Review.
• Microtubule polarity determines the lineage of embryonic neural precursor in zebrafish spinal cord.
  Richard CA, Seum C, Gonzalez-Gaitan M. Richard CA, et al. Commun Biol. 2024 Apr 10;7(1):439. doi: 10.1038/s42003-024-06018-7. Commun Biol. 2024. PMID: 38600297 Free PMC article.
• A cell fate decision map reveals abundant direct neurogenesis bypassing intermediate progenitors in the human developing neocortex.
  Coquand L, Brunet Avalos C, Macé AS, Farcy S, Di Cicco A, Lampic M, Wimmer R, Bessières B, Attie-Bitach T, Fraisier V, Sens P, Guimiot F, Brault JB, Baffet AD. Coquand L, et al. Nat Cell Biol. 2024 May;26(5):698-709. doi: 10.1038/s41556-024-01393-z. Epub 2024 Mar 28. Nat Cell Biol. 2024. PMID: 38548890 Free PMC article.
• Zebrafish as an emerging model to study estrogen receptors in neural development.
  Boueid MJ, El-Hage O, Schumacher M, Degerny C, Tawk M. Boueid MJ, et al. Front Endocrinol (Lausanne). 2023 Aug 17;14:1240018. doi: 10.3389/fendo.2023.1240018. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37664862 Free PMC article. Review.
• Apical size and deltaA expression predict adult neural stem cell decisions along lineage progression.
  Mancini L, Guirao B, Ortica S, Labusch M, Cheysson F, Bonnet V, Phan MS, Herbert S, Mahou P, Menant E, Bedu S, Tinevez JY, Baroud C, Beaurepaire E, Bellaiche Y, Bally-Cuif L, Dray N. Mancini L, et al. Sci Adv. 2023 Sep;9(35):eadg7519. doi: 10.1126/sciadv.adg7519. Epub 2023 Sep 1. Sci Adv. 2023. PMID: 37656795 Free PMC article.

References

1. 1. Genes Dev. 2009 Jun 15;23(12):1450-60 - PubMed
2. 1. Nature. 2001 Feb 8;409(6821):714-20 - PubMed
3. 1. Neuron. 2009 Jul 30;63(2):189-202 - PubMed
4. 1. Dev Dyn. 2006 Apr;235(4):967-77 - PubMed
5. 1. Curr Opin Neurobiol. 1997 Feb;7(1):29-39 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • H1 Connect

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • Gene Ontology
  • ZFIN