New technology for rapid molecular diagnosis of bloodstream infections - PubMed (original) (raw)
. 2010 May;10(4):399-415.
doi: 10.1586/erm.10.24.
Rangarajan Sampath, Haijing Li, Christian Massire, Heather E Matthews, Donna Toleno, Thomas A Hall, Lawrence B Blyn, Mark W Eshoo, Raymond Ranken, Steven A Hofstadler, Yi-Wei Tang
Affiliations
- PMID: 20465496
- DOI: 10.1586/erm.10.24
New technology for rapid molecular diagnosis of bloodstream infections
David J Ecker et al. Expert Rev Mol Diagn. 2010 May.
Abstract
Technologies for the correct and timely diagnosis of bloodstream infections are urgently needed. Molecular diagnostic methods have yet to have a major impact on the diagnosis of bloodstream infections; however, new methods are being developed that are beginning to address key issues. In this article, we discuss the key needs and objectives of molecular diagnostics for bloodstream infections and review some of the currently available methods and how these techniques meet key needs. We then focus on a new method that combines nucleic acid amplification with mass spectrometry in a novel approach to molecular diagnosis of bloodstream infections.
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