Targeting mitochondria for cancer therapy - PubMed (original) (raw)

Review

doi: 10.1038/nrd3137. Epub 2010 May 14.

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• PMID: 20467424
• DOI: 10.1038/nrd3137

Review

Targeting mitochondria for cancer therapy

Simone Fulda et al. Nat Rev Drug Discov. 2010 Jun.

Abstract

Mitochondria are the cells' powerhouse, but also their suicidal weapon store. Dozens of lethal signal transduction pathways converge on mitochondria to cause the permeabilization of the mitochondrial outer membrane, leading to the cytosolic release of pro-apoptotic proteins and to the impairment of the bioenergetic functions of mitochondria. The mitochondrial metabolism of cancer cells is deregulated owing to the use of glycolytic intermediates, which are normally destined for oxidative phosphorylation, in anabolic reactions. Activation of the cell death machinery in cancer cells by inhibiting tumour-specific alterations of the mitochondrial metabolism or by stimulating mitochondrial membrane permeabilization could therefore be promising therapeutic approaches.

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References

1. 1. Curr Opin Cell Biol. 2005 Dec;17(6):617-25 - PubMed
2. 1. Cell. 2006 Jul 14;126(1):177-89 - PubMed
3. 1. Semin Cancer Biol. 2009 Feb;19(1):57-66 - PubMed
4. 1. J Clin Oncol. 2007 May 1;25(13):1779-84 - PubMed
5. 1. Nature. 2005 Jun 2;435(7042):677-81 - PubMed

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