Post-translational modifications in signal integration - PubMed (original) (raw)
Review
doi: 10.1038/nsmb.1842. Epub 2010 May 23.
Affiliations
- PMID: 20495563
- DOI: 10.1038/nsmb.1842
Review
Post-translational modifications in signal integration
Yonathan Lissanu Deribe et al. Nat Struct Mol Biol. 2010 Jun.
Abstract
Post-translational modifications of proteins and the domains that recognize these modifications have central roles in creating a highly dynamic relay system that reads and responds to alterations in the cellular microenvironment. Here we review the common principles of post-translational modifications and their importance in signal integration underlying epidermal growth factor receptor signaling and endocytosis, DNA-damage responses and immunity.
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