Identification of palmatine as an inhibitor of West Nile virus - PubMed (original) (raw)

. 2010 Aug;155(8):1325-9.

doi: 10.1007/s00705-010-0702-4. Epub 2010 May 23.

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• PMID: 20496087
• DOI: 10.1007/s00705-010-0702-4

Identification of palmatine as an inhibitor of West Nile virus

Fan Jia et al. Arch Virol. 2010 Aug.

Abstract

In this study, we investigated the specific inhibition of West Nile virus (WNV) NS2B-NS3 protease and viral propagation by palmatine, a chemical compound from Coptis chinensis Franch. It was demonstrated that palmatine could inhibit WNV NS2B-NS3 protease activity in an uncompetitive manner, with a 50% inhibitory concentration (IC(50)) of 96 microM. Palmatine suppressed WNV without detectable cytotoxicity (a 50% effective concentration [EC(50)] of 3.6 microM and a 50% cytotoxicity concentration [CC(50)] of 1,031 microM). Furthermore, palmatine could also suppress dengue virus and yellow fever virus in a dose-dependent manner. This compound could potentially be developed for the treatment of flavivirus infections.

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