IL-17 signaling in host defense and inflammatory diseases - PubMed (original) (raw)

Review

IL-17 signaling in host defense and inflammatory diseases

Youcun Qian et al. Cell Mol Immunol. 2010 Sep.

Abstract

Interleukin (IL)-17, the signature cytokine secreted by T helper (Th) 17 cells, plays important roles in host defense against extracellular bacterial infection and fungal infection and contributes to the pathogenesis of various autoimmune inflammatory diseases. Here we review the recent advances in IL-17-mediated functions with emphasis on the studies of IL-17-mediated signal transduction, providing perspective on potential drug targets for the treatment of autoimmune inflammatory diseases.

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Figures

Figure 1

IL-17 family-mediated signaling. C/EBP, CCAAT/enhancer-binding proteins; ERK, extracellular signal-regulated kinase; GSK3β, glycogen synthase kinase 3β MAPK, mitogen-activated protein kinases; PI3K, phosphoinositide 3-kinase; TAK1, transforming growth factor-β-activated kinase-1; Th, T helper; TRAF6, tumor-necrosis factor receptor-associated factor 6.

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