Slow-cycling/quiescence balance of hematopoietic stem cells is related to physiological gradient of oxygen - PubMed (original) (raw)
Review
. 2010 Oct;38(10):847-51.
doi: 10.1016/j.exphem.2010.06.002. Epub 2010 Jun 12.
Affiliations
- PMID: 20547202
- DOI: 10.1016/j.exphem.2010.06.002
Review
Slow-cycling/quiescence balance of hematopoietic stem cells is related to physiological gradient of oxygen
Amélie V Guitart et al. Exp Hematol. 2010 Oct.
Abstract
Objective: Regulation of hematopoiesis depends on cytokines, cellular interactions, transcription, and metabolic factors. Among the latter, O(2) has been neglected for a long time. Recently, an increasing number of publications evidenced the regulatory role of physiological low O(2) concentrations (0.1-5%; similar to those in bone marrow) on the in vitro behavior of hematopoietic stem cells. This brief review utilizes the article of Eliasson and colleagues in this Journal to summarize the major results and questions about the relationships between O(2) and hematopoiesis.
Materials and methods: In order to be concise and interesting for readers unfamiliar with this field, we selected only the most significant data that either reinforce or contradict the conclusions of Eliasson et al., but we also provide references of reviews with a more detailed bibliography.
Results: A critical analysis of some key publications provides partial answers to three important questions: is the term hypoxia appropriate to describe physiological low O(2) concentrations? Is a very low O(2) level sufficient to control the quiescence/slow cycling balance of hematopoietic stem cells? Is the O(2) concentration able to modify the effect of cytokines on hematopoietic stem cells?
Conclusions: We propose to use in situ normoxia instead of the confusing term hypoxia when working with normal cells at physiological low O(2) concentrations. We suggest that a very low O(2) concentration is necessary but not sufficient to induce hematopoietic stem cell quiescence. We review some articles showing that O(2) variations modify the effect of cytokines.
Copyright © 2010 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
Comment on
- Hypoxia mediates low cell-cycle activity and increases the proportion of long-term-reconstituting hematopoietic stem cells during in vitro culture.
Eliasson P, Rehn M, Hammar P, Larsson P, Sirenko O, Flippin LA, Cammenga J, Jönsson JI. Eliasson P, et al. Exp Hematol. 2010 Apr;38(4):301-310.e2. doi: 10.1016/j.exphem.2010.01.005. Epub 2010 Feb 4. Exp Hematol. 2010. PMID: 20138114
Similar articles
- Hypoxia mediates low cell-cycle activity and increases the proportion of long-term-reconstituting hematopoietic stem cells during in vitro culture.
Eliasson P, Rehn M, Hammar P, Larsson P, Sirenko O, Flippin LA, Cammenga J, Jönsson JI. Eliasson P, et al. Exp Hematol. 2010 Apr;38(4):301-310.e2. doi: 10.1016/j.exphem.2010.01.005. Epub 2010 Feb 4. Exp Hematol. 2010. PMID: 20138114 - Interleukin-6 (IL-6) and low O(2) concentration (1%) synergize to improve the maintenance of hematopoietic stem cells (pre-CFC).
Kovacević-Filipović M, Petakov M, Hermitte F, Debeissat C, Krstić A, Jovcić G, Bugarski D, Lafarge X, Milenković P, Praloran V, Ivanović Z. Kovacević-Filipović M, et al. J Cell Physiol. 2007 Jul;212(1):68-75. doi: 10.1002/jcp.21003. J Cell Physiol. 2007. PMID: 17311290 - Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche.
Arai F, Suda T. Arai F, et al. Ann N Y Acad Sci. 2007 Jun;1106:41-53. doi: 10.1196/annals.1392.005. Epub 2007 Mar 1. Ann N Y Acad Sci. 2007. PMID: 17332071 Review. - Hematopoietic cytokines, transcription factors and lineage commitment.
Zhu J, Emerson SG. Zhu J, et al. Oncogene. 2002 May 13;21(21):3295-313. doi: 10.1038/sj.onc.1205318. Oncogene. 2002. PMID: 12032771 Review. - The stem cell continuum: cell cycle, injury, and phenotype lability.
Quesenberry PJ, Colvin G, Dooner G, Dooner M, Aliotta JM, Johnson K. Quesenberry PJ, et al. Ann N Y Acad Sci. 2007 Jun;1106:20-9. doi: 10.1196/annals.1392.016. Epub 2007 Mar 14. Ann N Y Acad Sci. 2007. PMID: 17360803 Review.
Cited by
- MYC: there is more to it than cancer.
Zacarías-Fluck MF, Soucek L, Whitfield JR. Zacarías-Fluck MF, et al. Front Cell Dev Biol. 2024 Mar 6;12:1342872. doi: 10.3389/fcell.2024.1342872. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 38510176 Free PMC article. Review. - Dormancy: There and Back Again.
Pshennikova ES, Voronina AS. Pshennikova ES, et al. Mol Biol. 2022;56(5):735-755. doi: 10.1134/S0026893322050119. Epub 2022 Oct 5. Mol Biol. 2022. PMID: 36217335 Free PMC article. - Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process.
Tan YZ, Xu XY, Dai JM, Yin Y, He XT, Zhang YL, Zhu TX, An Y, Tian BM, Chen FM. Tan YZ, et al. Stem Cell Res Ther. 2021 Apr 29;12(1):254. doi: 10.1186/s13287-021-02322-9. Stem Cell Res Ther. 2021. PMID: 33926537 Free PMC article. - Hypoxia promotes erythroid differentiation through the development of progenitors and proerythroblasts.
Bapat A, Schippel N, Shi X, Jasbi P, Gu H, Kala M, Sertil A, Sharma S. Bapat A, et al. Exp Hematol. 2021 May;97:32-46.e35. doi: 10.1016/j.exphem.2021.02.012. Epub 2021 Mar 3. Exp Hematol. 2021. PMID: 33675821 Free PMC article. - Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion.
Liao N, Shi Y, Zhang C, Zheng Y, Wang Y, Zhao B, Zeng Y, Liu X, Liu J. Liao N, et al. Stem Cell Res Ther. 2019 Oct 17;10(1):306. doi: 10.1186/s13287-019-1404-9. Stem Cell Res Ther. 2019. PMID: 31623678 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical