Subtype-specific dendritic Ca(2+) dynamics of inhibitory interneurons in the rat visual cortex - PubMed (original) (raw)
. 2010 Aug;104(2):840-53.
doi: 10.1152/jn.00146.2010. Epub 2010 Jun 16.
Affiliations
- PMID: 20554844
- DOI: 10.1152/jn.00146.2010
Free article
Subtype-specific dendritic Ca(2+) dynamics of inhibitory interneurons in the rat visual cortex
Kwang-Hyun Cho et al. J Neurophysiol. 2010 Aug.
Free article
Abstract
The Ca(2+) increase in dendrites that is evoked by the backpropagation of somatic action potentials (APs) is involved in the activity-dependent modulation of dendritic and synaptic functions that are location dependent. In the present study, we investigated dendritic Ca(2+) dynamics evoked by backpropagating APs (bAPs) in four subtypes of inhibitory interneurons classified by their spiking patterns: fast spiking (FS), late spiking (LS), burst spiking (BS), and regular-spiking nonpyramidal (RSNP) cells. Cluster analysis, single-cell RT-PCR, and immunohistochemistry confirmed the least-overlapping nature of the grouped cell populations. Somatic APs evoked dendritic Ca(2+) transients in all subtypes of inhibitory interneurons with different spatial profiles along the tree: constantly linear in FS and LS cells, increasing to a plateau in BS cells and bell-shaped in RSNP cells. The increases in bAP-evoked dendritic Ca(2+) transients brought about by the blocking of A-type K(+) channels were similar in whole dendritic trees of each subtype of inhibitory interneurons. However, in RSNP cells, the increases in the distal dendrites were larger than those in the proximal dendrites. On cholinergic activation, nicotinic inhibition of bAP-evoked dendritic Ca(2+) transients was observed only in BS cells expressing cholecystokinin and vasoactive intestinal peptide mRNAs, with no muscarinic modulation in all subtypes of inhibitory interneurons. Cell subtype-specific differential spatial profiles and their modulation in bAP-evoked dendritic Ca(2+) transients might be important for the domain-specific modulation of segregated inputs in inhibitory interneurons and differential control between the excitatory and inhibitory networks in the visual cortex.
Similar articles
- Differential cholinergic modulation of Ca2+ transients evoked by backpropagating action potentials in apical and basal dendrites of cortical pyramidal neurons.
Cho KH, Jang HJ, Lee EH, Yoon SH, Hahn SJ, Jo YH, Kim MS, Rhie DJ. Cho KH, et al. J Neurophysiol. 2008 Jun;99(6):2833-43. doi: 10.1152/jn.00063.2008. Epub 2008 Apr 16. J Neurophysiol. 2008. PMID: 18417635 - Estimating intracellular Ca2+ concentrations and buffering in a dendritic inhibitory hippocampal interneuron.
Liao CW, Lien CC. Liao CW, et al. Neuroscience. 2009 Dec 29;164(4):1701-11. doi: 10.1016/j.neuroscience.2009.09.052. Epub 2009 Sep 25. Neuroscience. 2009. PMID: 19782725 - Dendritic calcium mechanisms and long-term potentiation in cortical inhibitory interneurons.
Topolnik L. Topolnik L. Eur J Neurosci. 2012 Feb;35(4):496-506. doi: 10.1111/j.1460-9568.2011.07988.x. Epub 2012 Feb 6. Eur J Neurosci. 2012. PMID: 22304664 Review. - Synaptic integration in cortical inhibitory neuron dendrites.
Hu H, Vervaeke K. Hu H, et al. Neuroscience. 2018 Jan 1;368:115-131. doi: 10.1016/j.neuroscience.2017.06.065. Epub 2017 Jul 27. Neuroscience. 2018. PMID: 28756117 Review.
Cited by
- Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cell.
Petousakis KE, Park J, Papoutsi A, Smirnakis S, Poirazi P. Petousakis KE, et al. Elife. 2023 Dec 6;12:e91627. doi: 10.7554/eLife.91627. Elife. 2023. PMID: 38054403 Free PMC article. - A Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons.
Bartholome O, de la Brassinne Bonardeaux O, Neirinckx V, Rogister B. Bartholome O, et al. Cereb Cortex Commun. 2020 Jun 19;1(1):tgaa026. doi: 10.1093/texcom/tgaa026. eCollection 2020. Cereb Cortex Commun. 2020. PMID: 34296100 Free PMC article. - Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons.
Park J, Papoutsi A, Ash RT, Marin MA, Poirazi P, Smirnakis SM. Park J, et al. Nat Commun. 2019 Nov 26;10(1):5372. doi: 10.1038/s41467-019-13029-0. Nat Commun. 2019. PMID: 31772192 Free PMC article. - Inhibitory control of correlated intrinsic variability in cortical networks.
Stringer C, Pachitariu M, Steinmetz NA, Okun M, Bartho P, Harris KD, Sahani M, Lesica NA. Stringer C, et al. Elife. 2016 Dec 7;5:e19695. doi: 10.7554/eLife.19695. Elife. 2016. PMID: 27926356 Free PMC article. - Cell type specificity of neurovascular coupling in cerebral cortex.
Uhlirova H, Kılıç K, Tian P, Thunemann M, Desjardins M, Saisan PA, Sakadžić S, Ness TV, Mateo C, Cheng Q, Weldy KL, Razoux F, Vandenberghe M, Cremonesi JA, Ferri CG, Nizar K, Sridhar VB, Steed TC, Abashin M, Fainman Y, Masliah E, Djurovic S, Andreassen OA, Silva GA, Boas DA, Kleinfeld D, Buxton RB, Einevoll GT, Dale AM, Devor A. Uhlirova H, et al. Elife. 2016 May 31;5:e14315. doi: 10.7554/eLife.14315. Elife. 2016. PMID: 27244241 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous