FOXP3+ regulatory T cells in the human immune system - PubMed (original) (raw)

Review

. 2010 Jul;10(7):490-500.

doi: 10.1038/nri2785. Epub 2010 Jun 18.

Affiliations

• PMID: 20559327
• DOI: 10.1038/nri2785

Review

FOXP3+ regulatory T cells in the human immune system

Shimon Sakaguchi et al. Nat Rev Immunol. 2010 Jul.

Abstract

Forkhead box P3 (FOXP3)(+) regulatory T (T(Reg)) cells are potent mediators of dominant self tolerance in the periphery. But confusion as to the identity, stability and suppressive function of human T(Reg) cells has, to date, impeded the general therapeutic use of these cells. Recent studies have suggested that human T(Reg) cells are functionally and phenotypically diverse. Here we discuss recent findings regarding human T(Reg) cells, including the ontogeny and development of T(Reg) cell subsets that have naive or memory phenotypes, the unique mechanisms of suppression mediated by T(Reg) cell subsets and factors that regulate T(Reg) cell lineage commitment. We discuss future studies that are needed for the successful therapeutic use of human T(Reg) cells.

PubMed Disclaimer

Similar articles

• Interleukin-7 matures suppressive CD127(+) forkhead box P3 (FoxP3)(+) T cells into CD127(-) CD25(high) FoxP3(+) regulatory T cells.
  Di Caro V, D'Anneo A, Phillips B, Engman C, Harnaha J, Lakomy R, Styche A, Trucco M, Giannoukakis N. Di Caro V, et al. Clin Exp Immunol. 2011 Jul;165(1):60-76. doi: 10.1111/j.1365-2249.2011.04334.x. Epub 2011 Mar 17. Clin Exp Immunol. 2011. PMID: 21413939 Free PMC article.
• Plasticity of T(reg) cells: is reprogramming of T(reg) cells possible in the presence of FOXP3?
  Beyer M, Schultze JL. Beyer M, et al. Int Immunopharmacol. 2011 May;11(5):555-60. doi: 10.1016/j.intimp.2010.11.024. Epub 2010 Nov 27. Int Immunopharmacol. 2011. PMID: 21115121 Review.
• CD4(+)CD25 (+) regulatory T cells in human lupus erythematosus.
  Kuhn A, Beissert S, Krammer PH. Kuhn A, et al. Arch Dermatol Res. 2009 Jan;301(1):71-81. doi: 10.1007/s00403-008-0891-9. Epub 2008 Nov 5. Arch Dermatol Res. 2009. PMID: 18985367 Review.
• TCR repertoire and Foxp3 expression define functionally distinct subsets of CD4+ regulatory T cells.
  Kuczma M, Pawlikowska I, Kopij M, Podolsky R, Rempala GA, Kraj P. Kuczma M, et al. J Immunol. 2009 Sep 1;183(5):3118-29. doi: 10.4049/jimmunol.0900514. Epub 2009 Jul 31. J Immunol. 2009. PMID: 19648277 Free PMC article.
• Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10.
  Maynard CL, Harrington LE, Janowski KM, Oliver JR, Zindl CL, Rudensky AY, Weaver CT. Maynard CL, et al. Nat Immunol. 2007 Sep;8(9):931-41. doi: 10.1038/ni1504. Epub 2007 Aug 12. Nat Immunol. 2007. PMID: 17694059

Cited by

• Balancing functions of regulatory T cells in mosquito-borne viral infections.
  Sann S, Kleinewietfeld M, Cantaert T. Sann S, et al. Emerg Microbes Infect. 2024 Dec;13(1):2304061. doi: 10.1080/22221751.2024.2304061. Epub 2024 Jan 25. Emerg Microbes Infect. 2024. PMID: 38192073 Free PMC article. Review.
• The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance.
  Janikashvili N, Bonnotte B, Katsanis E, Larmonier N. Janikashvili N, et al. Clin Dev Immunol. 2011;2011:430394. doi: 10.1155/2011/430394. Epub 2011 Nov 3. Clin Dev Immunol. 2011. PMID: 22110524 Free PMC article. Review.
• Mechanisms of T cell organotropism.
  Fu H, Ward EJ, Marelli-Berg FM. Fu H, et al. Cell Mol Life Sci. 2016 Aug;73(16):3009-33. doi: 10.1007/s00018-016-2211-4. Epub 2016 Apr 1. Cell Mol Life Sci. 2016. PMID: 27038487 Free PMC article. Review.
• The difference of lymphocyte subsets including regulatory T-cells in umbilical cord blood between AGA neonates and SGA neonates.
  Yoon SH, Hur M, Hwang HS, Kwon HS, Sohn IS. Yoon SH, et al. Yonsei Med J. 2015 May;56(3):798-804. doi: 10.3349/ymj.2015.56.3.798. Yonsei Med J. 2015. PMID: 25837188 Free PMC article.
• In situ differentiation of CD8αα Τ cells from CD4 T cells in peripheral lymphoid tissues.
  Nambu Y, Hayashi T, Jang KJ, Aoki K, Mano H, Nakano K, Osato M, Takahashi K, Itoh K, Teramukai S, Komori T, Fujita J, Ito Y, Shimizu A, Sugai M. Nambu Y, et al. Sci Rep. 2012;2:642. doi: 10.1038/srep00642. Epub 2012 Sep 7. Sci Rep. 2012. PMID: 22962636 Free PMC article.

References

1. 1. Cell Immunol. 2008 Feb;251(2):109-15 - PubMed
2. 1. J Clin Invest. 2003 Nov;112(9):1437-43 - PubMed
3. 1. Cell. 2008 May 30;133(5):775-87 - PubMed
4. 1. Pediatrics. 1979 Nov;64(5 Pt 2 Suppl):795-802 - PubMed
5. 1. Nat Immunol. 2009 Jul;10(7):689-95 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database