Long-term depression in the CNS - PubMed (original) (raw)
Review
doi: 10.1038/nrn2867.
Affiliations
- PMID: 20559335
- DOI: 10.1038/nrn2867
Review
Long-term depression in the CNS
Graham L Collingridge et al. Nat Rev Neurosci. 2010 Jul.
Abstract
Long-term depression (LTD) in the CNS has been the subject of intense investigation as a process that may be involved in learning and memory and in various pathological conditions. Several mechanistically distinct forms of this type of synaptic plasticity have been identified and their molecular mechanisms are starting to be unravelled. Most studies have focused on forms of LTD that are triggered by synaptic activation of either NMDARs (N-methyl-D-aspartate receptors) or metabotropic glutamate receptors (mGluRs). Converging evidence supports a crucial role of LTD in some types of learning and memory and in situations in which cognitive demands require a flexible response. In addition, LTD may underlie the cognitive effects of acute stress, the addictive potential of some drugs of abuse and the elimination of synapses in neurodegenerative diseases.
Similar articles
- Interneuronal NMDA receptors regulate long-term depression and motor learning in the cerebellum.
Kono M, Kakegawa W, Yoshida K, Yuzaki M. Kono M, et al. J Physiol. 2019 Feb;597(3):903-920. doi: 10.1113/JP276794. Epub 2018 Nov 24. J Physiol. 2019. PMID: 30382582 Free PMC article. - NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD).
Lüscher C, Malenka RC. Lüscher C, et al. Cold Spring Harb Perspect Biol. 2012 Jun 1;4(6):a005710. doi: 10.1101/cshperspect.a005710. Cold Spring Harb Perspect Biol. 2012. PMID: 22510460 Free PMC article. - mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning.
Ayala JE, Chen Y, Banko JL, Sheffler DJ, Williams R, Telk AN, Watson NL, Xiang Z, Zhang Y, Jones PJ, Lindsley CW, Olive MF, Conn PJ. Ayala JE, et al. Neuropsychopharmacology. 2009 Aug;34(9):2057-71. doi: 10.1038/npp.2009.30. Epub 2009 Mar 18. Neuropsychopharmacology. 2009. PMID: 19295507 Free PMC article. - Hippocampal long-term synaptic plasticity and signal amplification of NMDA receptors.
MacDonald JF, Jackson MF, Beazely MA. MacDonald JF, et al. Crit Rev Neurobiol. 2006;18(1-2):71-84. doi: 10.1615/critrevneurobiol.v18.i1-2.80. Crit Rev Neurobiol. 2006. PMID: 17725510 Review. - Central neuronal plasticity, low back pain and spinal manipulative therapy.
Boal RW, Gillette RG. Boal RW, et al. J Manipulative Physiol Ther. 2004 Jun;27(5):314-26. doi: 10.1016/j.jmpt.2004.04.005. J Manipulative Physiol Ther. 2004. PMID: 15195039 Review.
Cited by
- The two faces of synaptic failure in AppNL-G-F knock-in mice.
Latif-Hernandez A, Sabanov V, Ahmed T, Craessaerts K, Saito T, Saido T, Balschun D. Latif-Hernandez A, et al. Alzheimers Res Ther. 2020 Aug 24;12(1):100. doi: 10.1186/s13195-020-00667-6. Alzheimers Res Ther. 2020. PMID: 32838792 Free PMC article. - Effect of the initial synaptic state on the probability to induce long-term potentiation and depression.
Migliore M, De Simone G, Migliore R. Migliore M, et al. Biophys J. 2015 Mar 10;108(5):1038-46. doi: 10.1016/j.bpj.2014.12.048. Biophys J. 2015. PMID: 25762316 Free PMC article. - Synaptic Plasticity and its Modulation by Alcohol.
Avchalumov Y, Mandyam CD. Avchalumov Y, et al. Brain Plast. 2020 Dec 29;6(1):103-111. doi: 10.3233/BPL-190089. Brain Plast. 2020. PMID: 33680849 Free PMC article. Review. - Disruption of Long-Term Depression Potentiates Latent Inhibition: Key Role for Central Nucleus of the Amygdala.
Ashby DM, Dias C, Aleksandrova LR, Lapish CC, Wang YT, Phillips AG. Ashby DM, et al. Int J Neuropsychopharmacol. 2021 Jul 23;24(7):580-591. doi: 10.1093/ijnp/pyab011. Int J Neuropsychopharmacol. 2021. PMID: 33693669 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources