Just when you thought it was safe to go into the membrane: the growing complexities of extra-nuclear progesterone signaling - PubMed (original) (raw)

Editorial

Just when you thought it was safe to go into the membrane: the growing complexities of extra-nuclear progesterone signaling

Aritro Sen et al. Breast Cancer Res. 2010.

Abstract

The diversity of membrane-initiated progesterone actions has made characterization and establishment of its biological importance a complicated endeavor. A new study by Zuo and colleagues shows that progesterone via endogenous membrane progesterone receptor-alpha acts as a negative regulator of proliferation and epithelial to mesenchymal transition in a breast cancer cell line. These progesterone-mediated actions appear to be regulated through epidermal growth factor receptor and phosphatidylinositol 3-kinase signaling localized in caveolae. Moreover, the study shows expression of membrane progesterone receptor-alpha in benign and malignant breast cancer tissues. These data bring forth novel concepts with regard to progesterone actions in the breast; however, further work is warranted to fully characterize the physiologic actions of extra-nuclear progesterone signaling in the breast.

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