Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers - PubMed (original) (raw)

. 2010 Jul 1;172(1):81-93.

doi: 10.1093/aje/kwq120. Epub 2010 Jun 18.

Eric J Jacobs, Alan A Arslan, Dai Qi, Alpa V Patel, Kathy J Helzlsouer, Stephanie J Weinstein, Marjorie L McCullough, Mark P Purdue, Xiao-Ou Shu, Kirk Snyder, Jarmo Virtamo, Lynn R Wilkins, Kai Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Demetrius Albanes, Qiuyin Cai, Chinonye Harvey, Richard Hayes, Sandra Clipp, Ronald L Horst, Lonn Irish, Karen Koenig, Loic Le Marchand, Laurence N Kolonel

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Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Rachael Z Stolzenberg-Solomon et al. Am J Epidemiol. 2010.

Abstract

Results from epidemiologic studies examining pancreatic cancer risk and vitamin D intake or 25-hydroxyvitamin D (25(OH)D) concentrations (the best indicator of vitamin D derived from diet and sun) have been inconsistent. Therefore, the authors conducted a pooled nested case-control study of participants from 8 cohorts within the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP) (1974-2006) to evaluate whether prediagnostic circulating 25(OH)D concentrations were associated with the development of pancreatic cancer. In total, 952 incident pancreatic adenocarcinoma cases occurred among participants (median follow-up, 6.5 years). Controls (n = 1,333) were matched to each case by cohort, age, sex, race/ethnicity, date of blood draw, and follow-up time. Conditional logistic regression analysis was used to calculate smoking-, body mass index-, and diabetes-adjusted odds ratios and 95% confidence intervals for pancreatic cancer. Clinically relevant 25(OH)D cutpoints were compared with a referent category of 50-<75 nmol/L. No significant associations were observed for participants with lower 25(OH)D status. However, a high 25(OH)D concentration (> or =100 nmol/L) was associated with a statistically significant 2-fold increase in pancreatic cancer risk overall (odds ratio = 2.12, 95% confidence interval: 1.23, 3.64). Given this result, recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer should be carefully considered.

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Figures

Figure 1.

Figure 1.

Forest plots for meta-analysis of the association between circulating 25-hydroxyvitamin D (25(OH)D) concentrations and risk of pancreatic cancer within the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers, 1974–2006. Odds ratios (squares) and 95% confidence intervals (bars) were derived from conditional logistic regression models adjusted for body mass index (weight (kg)/height (m)2) in World Health Organization categories (<18.5, 18.5–<25.0, 25.0–30.0, 30.0–<35.0, or ≥35.0, or missing data), smoking (never smoker, former smoker who had quit ≥15 years previously, former smoker who had quit 1–14 years previously, former smoker who had quit <1 year previously or current smoker of <20 cigarettes/day, and former smoker who had quit <1 year previously or current smoker of ≥20 cigarettes/day), and diabetes status (yes, no, or missing data). The size of each square is inversely proportional to the variance of the log odds ratio estimate in each cohort. The pooled estimates (diamonds) were derived from a meta-analysis using random-effects modeling. For each cohort, the plots show estimates for subjects with circulating 25(OH)D concentrations of A) <25 nmol/L and B) ≥100 nmol/L in comparison with the reference group (50–<75 nmol/L). ATBC, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, CI, confidence interval; CPS-II, Cancer Prevention Study II Nutrition Cohort; MEC, Multiethnic Cohort Study; NYU-WHS, New York University Women's Health Study; OR, odds ratio; PLCO, Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial; SM/WHS, Shanghai Men's Health Study and Shanghai Women's Health Study. SM/WHS data were excluded from the analysis of high 25(OH)D concentrations because of unstable estimates due to small numbers.

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