Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor - PubMed (original) (raw)
. 2010 Jul 22;53(14):5352-5.
doi: 10.1021/jm100249w.
Affiliations
- PMID: 20565110
- DOI: 10.1021/jm100249w
Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor
Tobias Karlberg et al. J Med Chem. 2010.
Abstract
We report two crystal structures of the PARP domain of human tankyrase-2 (TNKS2). Tankyrases are involved in fundamental cellular processes such as telomere homeostasis and Wnt signaling. The complex of TNKS2 with the potent inhibitor XAV939 provides insights into the molecular basis of the strong interaction and suggests routes for further development of tankyrase inhibitors.
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