Immune cell crosstalk in type 1 diabetes - PubMed (original) (raw)

Review

doi: 10.1038/nri2787.

Affiliations

Review

Immune cell crosstalk in type 1 diabetes

Agnès Lehuen et al. Nat Rev Immunol. 2010 Jul.

Abstract

The development of type 1 diabetes involves a complex interaction between pancreatic beta-cells and cells of both the innate and adaptive immune systems. Analyses of the interactions between natural killer (NK) cells, NKT cells, different dendritic cell populations and T cells have highlighted how these different cell populations can influence the onset of autoimmunity. There is evidence that infection can have either a potentiating or inhibitory role in the development of type 1 diabetes. Interactions between pathogens and cells of the innate immune system, and how this can influence whether T cell activation or tolerance occurs, have been under close scrutiny in recent years. This Review focuses on the nature of this crosstalk between the innate and the adaptive immune responses and how pathogens influence the process.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Exp Med. 1996 Nov 1;184(5):2049-53 - PubMed
    1. J Exp Med. 1998 Oct 19;188(8):1493-501 - PubMed
    1. Nat Med. 2001 Sep;7(9):1052-6 - PubMed
    1. J Exp Med. 1998 Apr 6;187(7):1047-56 - PubMed
    1. Diabetes. 1990 May;39(5):583-9 - PubMed

Publication types

MeSH terms

Grants and funding

LinkOut - more resources