Microtubule-binding natural products for cancer therapy - PubMed (original) (raw)

Review

. 2010 Aug;76(11):1037-43.

doi: 10.1055/s-0030-1250073. Epub 2010 Jun 24.

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• PMID: 20577942
• DOI: 10.1055/s-0030-1250073

Review

Microtubule-binding natural products for cancer therapy

Qing-Xi Yue et al. Planta Med. 2010 Aug.

Abstract

Natural products, especially microtubule-binding natural products, play important roles in the war against cancer. From the clinical use of vinblastine in 1961, paclitaxel in 1992, to ixabepilone in 2007, microtubule-binding natural products have continually contributed to the development of cancer therapy. The present review summarizes the development of representative microtubule-binding natural products including agents binding to the colchicine-binding site, the VINCA alkaloid-binding site, the taxane-binding site and other binding sites. Future directions for the development of new anticancer microtubule-binding natural products are discussed. Finding new formulations, new targets and new sources of microtubule-binding natural products may enable more members of this kind of agent to be introduced into the clinic for cancer therapy.

Georg Thieme Verlag KG Stuttgart-New York.

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