Two to tango: regulation of Mammalian iron metabolism - PubMed (original) (raw)
Review
. 2010 Jul 9;142(1):24-38.
doi: 10.1016/j.cell.2010.06.028.
Affiliations
- PMID: 20603012
- DOI: 10.1016/j.cell.2010.06.028
Free article
Review
Two to tango: regulation of Mammalian iron metabolism
Matthias W Hentze et al. Cell. 2010.
Free article
Abstract
Disruptions in iron homeostasis from both iron deficiency and overload account for some of the most common human diseases. Iron metabolism is balanced by two regulatory systems, one that functions systemically and relies on the hormone hepcidin and the iron exporter ferroportin, and another that predominantly controls cellular iron metabolism through iron-regulatory proteins that bind iron-responsive elements in regulated messenger RNAs. We describe how the two distinct systems function and how they "tango" together in a coordinated manner. We also highlight some of the current questions in mammalian iron metabolism and discuss therapeutic opportunities arising from a better understanding of the underlying biological principles.
Copyright 2010 Elsevier Inc. All rights reserved.
Similar articles
- The molecular basis of iron overload disorders and iron-linked anemias.
Kaplan J, Ward DM, De Domenico I. Kaplan J, et al. Int J Hematol. 2011 Jan;93(1):14-20. doi: 10.1007/s12185-010-0760-0. Epub 2011 Jan 7. Int J Hematol. 2011. PMID: 21210258 Review. - Hepcidin and iron homeostasis.
Ganz T, Nemeth E. Ganz T, et al. Biochim Biophys Acta. 2012 Sep;1823(9):1434-43. doi: 10.1016/j.bbamcr.2012.01.014. Epub 2012 Jan 26. Biochim Biophys Acta. 2012. PMID: 22306005 Free PMC article. Review. - Regulation of hepcidin and iron-overload disease.
Lee PL, Beutler E. Lee PL, et al. Annu Rev Pathol. 2009;4:489-515. doi: 10.1146/annurev.pathol.4.110807.092205. Annu Rev Pathol. 2009. PMID: 19400694 Review. - Hepcidin and Hfe in iron overload in beta-thalassemia.
Gardenghi S, Ramos P, Follenzi A, Rao N, Rachmilewitz EA, Giardina PJ, Grady RW, Rivella S. Gardenghi S, et al. Ann N Y Acad Sci. 2010 Aug;1202:221-5. doi: 10.1111/j.1749-6632.2010.05595.x. Ann N Y Acad Sci. 2010. PMID: 20712796 Free PMC article. Review. - Hepcidin in human iron disorders: therapeutic implications.
Pietrangelo A. Pietrangelo A. J Hepatol. 2011 Jan;54(1):173-81. doi: 10.1016/j.jhep.2010.08.004. Epub 2010 Aug 26. J Hepatol. 2011. PMID: 20932599 Review.
Cited by
- CoA synthase plays a critical role in neurodevelopment and neurodegeneration.
Cavestro C, D'Amato M, Colombo MN, Cascone F, Moro AS, Levi S, Tiranti V, Di Meo I. Cavestro C, et al. Front Cell Neurosci. 2024 Sep 5;18:1458475. doi: 10.3389/fncel.2024.1458475. eCollection 2024. Front Cell Neurosci. 2024. PMID: 39301217 Free PMC article. - Characterization of serum proteomic and inflammatory profiling at early stage of iron deficiency in weaned piglets.
Liu G, Li L, Liu S, Dong Z, Zhou J, Gong C, Yin Y, Tang W, Wan D. Liu G, et al. Anim Nutr. 2024 Apr 16;18:380-389. doi: 10.1016/j.aninu.2024.04.004. eCollection 2024 Sep. Anim Nutr. 2024. PMID: 39296492 Free PMC article. - Preliminary Evidence of the Possible Roles of the Ferritinophagy-Iron Uptake Axis in Canine Testicular Cancer.
Leandri R, Power K, Buonocore S, De Vico G. Leandri R, et al. Animals (Basel). 2024 Sep 9;14(17):2619. doi: 10.3390/ani14172619. Animals (Basel). 2024. PMID: 39272404 Free PMC article. - Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila.
Ma Z, Wang W, Yang X, Rui M, Wang S. Ma Z, et al. Elife. 2024 Sep 10;13:RP93604. doi: 10.7554/eLife.93604. Elife. 2024. PMID: 39255019 Free PMC article. - IL-6 signaling accelerates iron overload by upregulating DMT1 in endothelial cells to promote aortic dissection.
Xie Q, Wang J, Li R, Liu H, Zhong Y, Xu Q, Ge Y, Li C, Sun L, Zhu J. Xie Q, et al. Int J Biol Sci. 2024 Aug 6;20(11):4222-4237. doi: 10.7150/ijbs.99511. eCollection 2024. Int J Biol Sci. 2024. PMID: 39247821 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical