Kidney stones associate with increased risk for myocardial infarction - PubMed (original) (raw)

Kidney stones associate with increased risk for myocardial infarction

Andrew D Rule et al. J Am Soc Nephrol. 2010 Oct.

Abstract

Kidney stones are a risk factor for chronic kidney disease (CKD), which, in turn, is a risk factor for myocardial infarction (MI). The objective of this study was to determine whether kidney stones associate with an increased risk for MI. We matched 4564 stone formers (1984 through 2003) on age and gender with 10,860 control subjects among residents in Olmsted County, Minnesota. We identified incident MI by diagnostic codes and validated events by chart review through 2006. We used diagnostic codes to determine incidence of kidney stones and presence of comorbidities (CKD, hypertension, diabetes, obesity, dyslipidemia, gout, alcohol dependence, and tobacco use). During a mean of 9 years of follow-up, stone formers had a 38% (95% confidence interval 7 to 77%) increased risk for MI, which remained at 31% (95% confidence interval 2% to 69%) after adjustment for CKD and other comorbidities. In conclusion, kidney stone formers are at increased risk for MI, and this risk is independent of CKD and other risk factors.

PubMed Disclaimer

Figures

Figure 1.

Increased risk for MI in stone formers than in controls among Olmsted County, Minnesota residents.

References

1. Rule AD, Bergstralh EJ, Melton LJ, 3rd, Li X, Weaver AL, Lieske JC: Kidney stones and the risk for chronic kidney disease. Clin J Am Soc Nephrol 4: 804–811, 2009 - PMC - PubMed
1. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY: Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351: 1296–1305, 2004 - PubMed
1. Foster MC, Hwang SJ, Larson MG, Parikh NI, Meigs JB, Vasan RS, Wang TJ, Levy D, Fox CS: Cross-classification of microalbuminuria and reduced glomerular filtration rate: Associations between cardiovascular disease risk factors and clinical outcomes. Arch Intern Med 167: 1386–1392, 2007 - PubMed
1. Roger VL: Coronary disease surveillance: A public heath imperative. Eur Heart J 28: 2051–2052, 2007 - PubMed
1. Roger VL, Jacobsen SJ, Weston SA, Goraya TY, Killian J, Reeder GS, Kottke TE, Yawn BP, Frye RL: Trends in the incidence and survival of patients with hospitalized myocardial infarction, Olmsted County, Minnesota, 1979 to 1994. Ann Intern Med 136: 341–348, 2002 - PubMed

Kidney stones associate with increased risk for myocardial infarction - PubMed (original) (raw)