Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation - PubMed (original) (raw)

Figure 3. STAT-bound genes represent multiple aspects of Th differentiation

ChIP-seq signal profile maps are shown as a genome browser view. (A) Th1 cell genes, Ifng (chr10:117,875,074-117,885,977), Tbx21 (chr11:96,947,000-96,996,774), Lag3 (chr6:124,848,219-124,863,009), Zbtb32 (chr7:31,374,500-31,385,000), Il21 (chr3:37,119,708-37,136,092), (B) Th2 cell genes, Il4 (chr11:53,418,425-53,444,775), Gata3 (chr2:9,770,098-9,802,379), Il24 (chr1:132,778,117-132,786,123), Plcd1 (chr9:118,980,999-119,011,401) and Hipk2 (chr6:38,641,845-38,850,017). STAT4 and STAT6 binding in wild-type is shown in red upward peaks. Epigenetic marks (H3K4me3, H3K36me3) in wild-type cells are depicted as red upward peaks whereas the accompanying blue colored downward peaks depict the binding in STAT4-deficient cells. Where no signal was detected, the corresponding columns are blank.