Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence - PubMed (original) (raw)
Review
Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence
Jie Qiao et al. Hum Reprod Update. 2011 Jan-Feb.
Abstract
Background: Polycystic ovary syndrome (PCOS) is a common metabolic dysfunction and heterogeneous endocrine disorder in women of reproductive age. Although patients with PCOS are typically characterized by increased numbers of oocytes retrieved during IVF, they are often of poor quality, leading to lower fertilization, cleavage and implantation rates, and a higher miscarriage rate.
Methods: For this review, we searched the database MEDLINE (1950 to January 2010) and Google for all full texts and/or abstract articles published in English with content related to oocyte maturation and embryo developmental competence.
Results: The search showed that alteration of many factors may directly or indirectly impair the competence of maturating oocytes through endocrine and local paracrine/autocrine actions, resulting in a lower pregnancy rate in patients with PCOS. The extra-ovarian factors identified included gonadotrophins, hyperandrogenemia and hyperinsulinemia, although intra-ovarian factors included members of the epidermal, fibroblast, insulin-like and neurotrophin families of growth factors, as well as the cytokines.
Conclusions: Any abnormality in the extra- and/or intra-ovarian factors may negatively affect the granulosa cell-oocyte interaction, oocyte maturation and potential embryonic developmental competence, contributing to unsuccessful outcomes for patients with PCOS who are undergoing assisted reproduction.
Figures
Figure 1
Intra-and extra-ovarian factors associated with the PCOS pathology that negatively affect oocyte and subsequent embryo quality.
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References
- Adams J, Franks S, Polson DW, Mason HD, Abdulwahid N, Tucker M, Morris DV, Price J, Jacobs HS. Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotropin releasing hormone. Lancet. 1985;ii:1375–1379. - PubMed
- Adashi EY. Intraovarian regulation: the proposed role of insulin-like growth factors. New York Acad Sci. 1993;687:10–13. doi:10.1111/j.1749-6632.1993.tb43847.x. - DOI - PubMed
- Agrawal R, Conway G, Sladkevicius P, Tan SL, Engmann L, Payne N, Bekir J, Campbell S, Jacobs H. Serum vascular endothelial growth factor and Doppler blood flow velocities in in vitro fertilization: relevance to ovarian hyperstimulation syndrome and polycystic ovaries. Fertil Steril. 1998;70:651–658. doi:10.1016/S0015-0282(98)00249-0. - DOI - PubMed
- Agrawal R, Jacobs H, Payne N, Conway G. Concentration of vascular endothelial growth factor released by cultured human luteinized granulosa cells is higher in women with polycystic ovaries than in women with normal ovaries. Fertil Steril. 2002;78:1164–1169. doi:10.1016/S0015-0282(02)04242-5. - DOI - PubMed
- Almahbobi G, Trounson AO. The role of intraovarian regulators in the etiology of the polycystic ovarian syndrome. Reprod Med Rev. 1996;5:151–168. doi:10.1017/S0962279900001320. - DOI
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