Signs and symptoms versus nerve conduction studies to diagnose diabetic sensorimotor polyneuropathy: Cl vs. NPhys trial - PubMed (original) (raw)

Comparative Study

doi: 10.1002/mus.21661.

Carol J Overland, Phillip A Low, William J Litchy, Jenny L Davies, P James B Dyck, Peter C O'Brien; Cl vs. NPhys Trial Investigators; James W Albers, Henning Andersen, Charles F Bolton, John D England, Christopher J Klein, J Gareth Llewelyn, Michelle L Mauermann, James W Russell, Wolfgang Singer, A Gordon Smith, Solomon Tesfaye, Adrian Vella

Collaborators, Affiliations

Comparative Study

Signs and symptoms versus nerve conduction studies to diagnose diabetic sensorimotor polyneuropathy: Cl vs. NPhys trial

Peter J Dyck et al. Muscle Nerve. 2010 Aug.

Abstract

The purpose was to test whether physicians can validly and reproducibly diagnose diabetic sensorimotor polyneuropathy (DSPN). Twelve physicians assessed 24 patients with diabetes mellitus (DM) on consecutive days (576 examinations) with physical features and voice disguised. Results were compared to gold standard 75% group diagnosis (dx) and a nerve conduction score (Sigma5 NC nds). Masking of patients was achieved. Reproducibility measured by the kappa coefficient and compared to Sigma5 NC nd varied considerably among physicians: median and ranges: signs 0.8 (0.32-1.0); symptoms 0.79 (0.36-1.0), and diagnoses 0.47 (0.33-0.84), both low and high scores indicating poor performance. There was substantial agreement between 75% group dx and confirmed NC abnormality (abn). As compared to Sigma5 NC, individual physicians' clinical dx was excessively variable and frequently inaccurate. Study physician dx from signs and symptoms were excessively variable, often overestimating DSPN. Specific approaches to improving clinical proficiency should be tested.

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Figures

Figure 1

Figure 1

Members of the surveillance team illustrate the dress and electronic voice distortion used at first examination to allow masked assessment of reproducibility on a subsequent evaluation the next day. This is described in more detail in text.

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