Actin microfilament dynamics in locomoting cells - PubMed (original) (raw)
. 1991 Jul 11;352(6331):126-31.
doi: 10.1038/352126a0.
Affiliations
- PMID: 2067574
- DOI: 10.1038/352126a0
Actin microfilament dynamics in locomoting cells
J A Theriot et al. Nature. 1991.
Abstract
The dynamic behaviour of actin filaments has been directly observed in living, motile cells using fluorescence photoactivation. In goldfish epithelial keratocytes, the actin microfilaments in the lamellipodium remain approximately fixed relative to the substrate as the cell moves over them, regardless of cell speed. The rate of turnover of actin subunits in the lamellipodium is remarkably rapid. Cell movement is directly and tightly coupled to the formation of new actin filaments at the leading edge.
Comment in
- Cell locomotion. Actin alone in lamellipodia.
Heath J, Holifield B. Heath J, et al. Nature. 1991 Jul 11;352(6331):107-8. doi: 10.1038/352107a0. Nature. 1991. PMID: 2067569 No abstract available.
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