Aminoguanidine effects on nerve blood flow, vascular permeability, electrophysiology, and oxygen free radicals - PubMed (original) (raw)
Aminoguanidine effects on nerve blood flow, vascular permeability, electrophysiology, and oxygen free radicals
M Kihara et al. Proc Natl Acad Sci U S A. 1991.
Abstract
Since advanced glycosylation end products have been suggested to mediate hyperglycemia-induced microvascular atherogenesis and because aminoguanidine (AG) prevents their generation, we examined whether AG could prevent or ameliorate the physiologic and biochemical indices of streptozotocin (STZ)-induced experimental diabetic neuropathy. Four groups of adult Sprague-Dawley rats were studied: group I received STZ plus AG (25 mg.kg-1.day-1), group II received STZ plus AG (50 mg.kg-1.day-1), group III received STZ alone, and group IV was a control. We monitored conduction and action potential amplitudes serially in sciatic-tibial and caudal nerves, nerve blood flow, oxygen free radical activity (conjugated dienes and hydroperoxides), and the product of the permeability coefficient and surface area to 125I-labeled albumin. STZ-induced diabetes (group III) caused a 57% reduction in nerve blood flow and in abnormal nerve conduction and amplitudes and a 60% increase in conjugated dienes. Nerve blood flow was normalized by 8 weeks with AG (groups I and II) and conduction was significantly improved, in a dose-dependent manner, by 16 and 24 weeks in sciatic-tibial and caudal nerves, respectively. The permeability coefficient was not impaired, suggesting a normal blood-nerve barrier function for albumin, and the oxygen free-radical indices were not ameliorated by AG. We suggest that AG reverses nerve ischemia and more gradually improves their electrophysiology by an action on nerve microvessels. AG may have potential in the treatment of diabetic neuropathy.
Similar articles
- Cause and effect of ischaemia in chronic experimental diabetic neuropathy.
Low P, Kihara M, Cameron N, Cotter M, Poduslo J. Low P, et al. Diabet Med. 1993;10 Suppl 2:52S-55S. doi: 10.1111/j.1464-5491.1993.tb00200.x. Diabet Med. 1993. PMID: 8334844 Review. No abstract available. - Endoneurial blood flow changes in diabetic rats.
Williamson JR, Chang K, Allison W, Kilo C. Williamson JR, et al. Diabet Med. 1993;10 Suppl 2:49S-51S. doi: 10.1111/j.1464-5491.1993.tb00199.x. Diabet Med. 1993. PMID: 8334843 Review. No abstract available.
Cited by
- Combination therapy is it in the future for successfully treating peripheral diabetic neuropathy?
Yorek M. Yorek M. Front Endocrinol (Lausanne). 2024 May 15;15:1357859. doi: 10.3389/fendo.2024.1357859. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38812811 Free PMC article. Review. - Glucose and Blood Pressure-Dependent Pathways-The Progression of Diabetic Kidney Disease.
Patel DM, Bose M, Cooper ME. Patel DM, et al. Int J Mol Sci. 2020 Mar 23;21(6):2218. doi: 10.3390/ijms21062218. Int J Mol Sci. 2020. PMID: 32210089 Free PMC article. Review. - Inhibiting Effect of Zinc Oxide Nanoparticles on Advanced Glycation Products and Oxidative Modifications: a Potential Tool to Counteract Oxidative Stress in Neurodegenerative Diseases.
Ashraf JM, Ansari MA, Fatma S, Abdullah SMS, Iqbal J, Madkhali A, Hamali AH, Ahmad S, Jerah A, Echeverria V, Barreto GE, Ashraf GM. Ashraf JM, et al. Mol Neurobiol. 2018 Sep;55(9):7438-7452. doi: 10.1007/s12035-018-0935-x. Epub 2018 Feb 8. Mol Neurobiol. 2018. PMID: 29423819 - Glycation, oxidation, and lipoxidation in the development of the complications of diabetes: a carbonyl stress hypothesis.
Lyons TJ, Jenkins AJ. Lyons TJ, et al. Diabetes Rev (Alex). 1997;5(4):365-391. Diabetes Rev (Alex). 1997. PMID: 26366051 Free PMC article. - Mechanism of diabetic neuropathy: Where are we now and where to go?
Yagihashi S, Mizukami H, Sugimoto K. Yagihashi S, et al. J Diabetes Investig. 2011 Jan 24;2(1):18-32. doi: 10.1111/j.2040-1124.2010.00070.x. J Diabetes Investig. 2011. PMID: 24843457 Free PMC article. Review.
References
- Lab Invest. 1966 Jan;15(1 Pt 1):132-48 - PubMed
- J Biol Chem. 1957 May;226(1):497-509 - PubMed
- Eur J Clin Invest. 1979 Jun;9(3):223-8 - PubMed
- J Lab Clin Med. 1980 Jun;95(6):950-8 - PubMed
- J Lab Clin Med. 1981 Jan;97(1):87-96 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical