Mitochondria and cell death: outer membrane permeabilization and beyond - PubMed (original) (raw)

Review

doi: 10.1038/nrm2952. Epub 2010 Aug 4.

Affiliations

Review

Mitochondria and cell death: outer membrane permeabilization and beyond

Stephen W G Tait et al. Nat Rev Mol Cell Biol. 2010 Sep.

Abstract

Mitochondrial outer membrane permeabilization (MOMP) is often required for activation of the caspase proteases that cause apoptotic cell death. Various intermembrane space (IMS) proteins, such as cytochrome c, promote caspase activation following their mitochondrial release. As a consequence, mitochondrial outer membrane integrity is highly controlled, primarily through interactions between pro- and anti-apoptotic members of the B cell lymphoma 2 (BCL-2) protein family. Following MOMP by pro-apoptotic BCL-2-associated X protein (BAX) or BCL-2 antagonist or killer (BAK), additional regulatory mechanisms govern the mitochondrial release of IMS proteins and caspase activity. MOMP typically leads to cell death irrespective of caspase activity by causing a progressive decline in mitochondrial function, although cells can survive this under certain circumstances, which may have pathophysiological consequences.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Cell Biol. 2009 Sep 21;186(6):805-16 - PubMed
    1. Cell. 2006 Jul 14;126(1):177-89 - PubMed
    1. Dev Cell. 2008 Feb;14(2):193-204 - PubMed
    1. Nat Cell Biol. 2000 Aug;2(8):553-5 - PubMed
    1. Cell Death Differ. 1999 Jul;6(7):683-8 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources