Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2 - PubMed (original) (raw)

. 2010 Sep;42(9):739-741.

doi: 10.1038/ng.639. Epub 2010 Aug 8.

Fredrik O Vannberg # 3, Sunny H Wong 3, Ellis Owusu-Dabo 4 5, Ivy Osei 6, John Gyapong 6, Giorgio Sirugo 7, Fatou Sisay-Joof 7, Anthony Enimil 4 8, Margaret A Chinbuah 6, Sian Floyd 9, David K Warndorff 10, Lifted Sichali 10, Simon Malema 10, Amelia C Crampin 9, Bagrey Ngwira 10, Yik Y Teo 3, Kerrin Small 3, Kirk Rockett 3, Dominic Kwiatkowski 3, Paul E Fine 9 10, Philip C Hill 7, Melanie Newport 7, Christian Lienhardt 7, Richard A Adegbola 7, Tumani Corrah 7, Andreas Ziegler 2; African TB Genetics Consortium; Wellcome Trust Case Control Consortium; Andrew P Morris 3, Christian G Meyer 1, Rolf D Horstmann # 1, Adrian V S Hill # 3

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Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2

Thorsten Thye et al. Nat Genet. 2010 Sep.

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Abstract

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

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Figure 1

Figure 1

Association plot with fine mapping markers on chromosome 18 in the combined analysis (_r_2 values between rs4331426 and adjacent SNPs derived from the Ghanaian population; P uncorrected for λGC).

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