The association of the angiopoietin/Tie-2 system with the development of metastasis and leukocyte migration in neuroendocrine tumors - PubMed (original) (raw)
. 2010 Oct 5;17(4):897-908.
doi: 10.1677/ERC-10-0020. Print 2010 Dec.
Affiliations
- PMID: 20696814
- DOI: 10.1677/ERC-10-0020
The association of the angiopoietin/Tie-2 system with the development of metastasis and leukocyte migration in neuroendocrine tumors
Nicté Figueroa-Vega et al. Endocr Relat Cancer. 2010.
Abstract
The aim of this study was to explore the possible involvement of the angiopoietin (Ang)-1, -2/Tie-2 system in the development, growth, and metastases evolution of gastroenteropancreatic-neuroendocrine tumors (GEP-NETs). We prospectively examined the serum levels of Tie-2, Ang-1, and Ang-2 by ELISA in 42 patients with proven GEP-NETs and 27 controls. We also determined the expression of the Ang/Tie-2 system in freshly isolated peripheral blood monocytes and in tumor cells from malignant primary tumors and/or liver metastases samples from GEP-NET patients by flow cytometry and/or RT-PCR. Furthermore, the function of the Ang/Tie-2 system in monocytes from controls and patients was assessed by a chemotaxis assay. GEP-NET patients showed enhanced serum levels of soluble form of Tie-2 (sTie-2), Ang-1, and Ang-2 (P<0.05 in all cases), compared to controls. sTie-2 and Ang-2 levels were significantly higher in GEP-NETs with metastases compared to those with no metastases. In addition, a significant correlation was detected between Ang-2 levels and chromogranin A or sTie-2 concentrations or 5-hydroxy-indole acetic acid excretion (r=0.71, r=0.60, and r=0.81 respectively, P<0.01 in all cases). Furthermore, we observed an enhanced expression of Ang-1, Ang-2, and Tie-2 in freshly isolated tumor cells from GEP-NET both by immunohistochemistry and by RT-PCR. Interestingly, an enhanced expression and function of Tie-2 was detected in monocytes from GEP-NET patients. Our data suggest that the Ang/Tie-2 system is involved in the growth and development of metastases of GEP-NETs, and that favors the recruitment of Tie-2(+) monocytes to the tumor site, where they can promote inflammation and angiogenesis.
Similar articles
- Differential expression of the Tie-2 receptor and its ligands in human pancreatic tumors.
Durkin AJ, Bloomston M, Yeatman TJ, Gilbert-Barness E, Cojita D, Rosemurgy AS, Zervos EE. Durkin AJ, et al. J Am Coll Surg. 2004 Nov;199(5):724-31. doi: 10.1016/j.jamcollsurg.2004.07.021. J Am Coll Surg. 2004. PMID: 15501112 - Reciprocal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat.
Sandhu R, Teichert-Kuliszewska K, Nag S, Proteau G, Robb MJ, Campbell AI, Kuliszewski MA, Kutryk MJ, Stewart DJ. Sandhu R, et al. Cardiovasc Res. 2004 Oct 1;64(1):115-24. doi: 10.1016/j.cardiores.2004.05.013. Cardiovasc Res. 2004. PMID: 15364619 - Angiopoietin 1 (Ang-1), angiopoietin 2 (Ang-2) and Tie-2 (a receptor tyrosine kinase) concentrations in peripheral blood of patients with thyroid cancers.
Niedźwiecki S, Stepień T, Kopeć K, Kuzdak K, Komorowski J, Krupiński R, Stepień H. Niedźwiecki S, et al. Cytokine. 2006 Dec;36(5-6):291-5. doi: 10.1016/j.cyto.2007.02.008. Epub 2007 Mar 19. Cytokine. 2006. PMID: 17374490 - Multiple roles of angiopoietins in atherogenesis.
Ahmed A, Fujisawa T. Ahmed A, et al. Curr Opin Lipidol. 2011 Oct;22(5):380-5. doi: 10.1097/MOL.0b013e32834b26b3. Curr Opin Lipidol. 2011. PMID: 21881497 Review. - Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors.
Klöppel G, Rindi G, Anlauf M, Perren A, Komminoth P. Klöppel G, et al. Virchows Arch. 2007 Aug;451 Suppl 1:S9-27. doi: 10.1007/s00428-007-0461-0. Epub 2007 Aug 8. Virchows Arch. 2007. PMID: 17684761 Review.
Cited by
- Risk Stratification of Pancreatic Neuroendocrine Neoplasms Based on Clinical, Pathological, and Molecular Characteristics.
Choi JH, Paik WH. Choi JH, et al. J Clin Med. 2022 Dec 15;11(24):7456. doi: 10.3390/jcm11247456. J Clin Med. 2022. PMID: 36556070 Free PMC article. Review. - Characterization of circulating immune cells and correlation with Tie2/Angiopoietins level in well differentiated neuroendocrine gastroenteropancreatic tumors: a cross-sectional analysis.
Sesti F, Puliani G, Feola T, Campolo F, Sciarra F, Hasenmajer V, Lenzi A, Faggiano A, Isidori AM, Venneri MA, Giannetta E. Sesti F, et al. Endocrine. 2023 Apr;80(1):221-230. doi: 10.1007/s12020-022-03257-8. Epub 2022 Dec 12. Endocrine. 2023. PMID: 36509928 - Circulating Angiogenic Markers in Gastroenteropancreatic Neuroendocrine Neoplasms: A Systematic Review.
Sandra I, Cazacu IM, Croitoru VM, Mihaila M, Herlea V, Diculescu MM, Dima SO, Croitoru AE. Sandra I, et al. Curr Issues Mol Biol. 2022 Sep 4;44(9):4001-4014. doi: 10.3390/cimb44090274. Curr Issues Mol Biol. 2022. PMID: 36135186 Free PMC article. Review. - Angiogenesis in NENs, with a focus on gastroenteropancreatic NENs: from biology to current and future therapeutic implications.
Lauricella E, Mandriani B, Cavallo F, Pezzicoli G, Chaoul N, Porta C, Cives M. Lauricella E, et al. Front Oncol. 2022 Aug 17;12:957068. doi: 10.3389/fonc.2022.957068. eCollection 2022. Front Oncol. 2022. PMID: 36059642 Free PMC article. Review. - An update on the diagnosis of gastroenteropancreatic neuroendocrine neoplasms.
Fang JM, Li J, Shi J. Fang JM, et al. World J Gastroenterol. 2022 Mar 14;28(10):1009-1023. doi: 10.3748/wjg.v28.i10.1009. World J Gastroenterol. 2022. PMID: 35431496 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous