Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats - PubMed (original) (raw)
. 2010 Oct 28;132(1):200-5.
doi: 10.1016/j.jep.2010.08.013. Epub 2010 Aug 14.
Affiliations
- PMID: 20713147
- DOI: 10.1016/j.jep.2010.08.013
Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats
Saeed Esmaeili-Mahani et al. J Ethnopharmacol. 2010.
Abstract
Aim of the study: Olive (Olea europaea) leaves are used as anti-rheumatic, anti-inflammatory, antinociceptive, antipyretic, vasodilatory, hypotensive, antidiuretic and hypoglycemic agents in traditional medicine. Recently, it has been shown that olive leaf extract (OLE) has calcium channel blocker property; however, its influences on nociceptive threshold and morphine effects have not yet been clarified.
Materials and methods: All experiments were carried out on male Wistar rats. The tail-flick, hot-plate and formalin tests were used to assess the effect of OLE on nociceptive threshold. To determine the effect of OLE on analgesic and hyperalgesic effects of morphine, OLE (6, 12 and 25 mg/kg i.p.) that had no significant nociceptive effect, was injected concomitant with morphine (5 mg/kg and 1 μg/kg i.p., respectively). The tail-flick test was used to assess the effect of OLE on anti- and pro-nociceptive effects of morphine.
Results: The data showed that OLE (50-200 mg/kg i.p.) could produce dose-dependent analgesic effect on tail-flick and hot-plate tests. Administration of 200 mg/kg OLE (i.p.) caused significant decrease in pain responses in the first and the second phases of formalin test. In addition, OLE could potentiate the antinociceptive effect of 5 mg/kg morphine and block low-dose morphine-induced hyperalgesia.
Conclusion: Our results indicate that olive leaf extract has analgesic property in several models of pain and useful influence on morphine analgesia in rats. Therefore, it can be used for the treatment and/or management of painful conditions.
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Similar articles
- Oleuropein, chief constituent of olive leaf extract, prevents the development of morphine antinociceptive tolerance through inhibition of morphine-induced L-type calcium channel overexpression.
Zare L, Esmaeili-Mahani S, Abbasnejad M, Rasoulian B, Sheibani V, Sahraei H, Kaeidi A. Zare L, et al. Phytother Res. 2012 Nov;26(11):1731-7. doi: 10.1002/ptr.4634. Epub 2012 Mar 15. Phytother Res. 2012. PMID: 22422486 - Olive (Olea europaea L.) leaf extract attenuates early diabetic neuropathic pain through prevention of high glucose-induced apoptosis: in vitro and in vivo studies.
Kaeidi A, Esmaeili-Mahani S, Sheibani V, Abbasnejad M, Rasoulian B, Hajializadeh Z, Afrazi S. Kaeidi A, et al. J Ethnopharmacol. 2011 Jun 14;136(1):188-96. doi: 10.1016/j.jep.2011.04.038. Epub 2011 Apr 22. J Ethnopharmacol. 2011. PMID: 21540099 - Antinociceptive, antiinflammatory and antidiabetic effects of Leonotis leonurus (L.) R. BR. [Lamiaceae] leaf aqueous extract in mice and rats.
Ojewole JA. Ojewole JA. Methods Find Exp Clin Pharmacol. 2005 May;27(4):257-64. doi: 10.1358/mf.2005.27.4.893583. Methods Find Exp Clin Pharmacol. 2005. PMID: 16082426 - Olive tree (Olea europaea) leaves: potential beneficial effects on human health.
El SN, Karakaya S. El SN, et al. Nutr Rev. 2009 Nov;67(11):632-8. doi: 10.1111/j.1753-4887.2009.00248.x. Nutr Rev. 2009. PMID: 19906250 Review. - [Research progress on biological activities of Olea europaea leaf extract].
Zheng J, Wei JT, Liu JF, Liu YW. Zheng J, et al. Zhongguo Zhong Yao Za Zhi. 2016 Feb;41(4):613-618. doi: 10.4268/cjcmm20160411. Zhongguo Zhong Yao Za Zhi. 2016. PMID: 28871681 Review. Chinese.
Cited by
- Pharmacological Interventions for Opioid-Induced Hyperalgesia: A Scoping Review of Preclinical Trials.
Koponen ME, Forget P. Koponen ME, et al. J Clin Med. 2022 Nov 29;11(23):7060. doi: 10.3390/jcm11237060. J Clin Med. 2022. PMID: 36498635 Free PMC article. Review. - Valorizing the usage of olive leaves, bioactive compounds, biological activities, and food applications: A comprehensive review.
Selim S, Albqmi M, Al-Sanea MM, Alnusaire TS, Almuhayawi MS, AbdElgawad H, Al Jaouni SK, Elkelish A, Hussein S, Warrad M, El-Saadony MT. Selim S, et al. Front Nutr. 2022 Nov 8;9:1008349. doi: 10.3389/fnut.2022.1008349. eCollection 2022. Front Nutr. 2022. PMID: 36424930 Free PMC article. Review. - Traditional Medicinal Plants as a Source of Inspiration for Osteosarcoma Therapy.
Kazantseva L, Becerra J, Santos-Ruiz L. Kazantseva L, et al. Molecules. 2022 Aug 6;27(15):5008. doi: 10.3390/molecules27155008. Molecules. 2022. PMID: 35956961 Free PMC article. Review. - Olea europea L. Leaves and Hibiscus sabdariffa L. Petals Extracts: Herbal Mix from Cardiovascular Network Target to Gut Motility Dysfunction Application.
Mattioli LB, Frosini M, Amoroso R, Maccallini C, Chiano E, Aldini R, Urso F, Corazza I, Micucci M, Budriesi R. Mattioli LB, et al. Nutrients. 2022 Jan 21;14(3):463. doi: 10.3390/nu14030463. Nutrients. 2022. PMID: 35276825 Free PMC article. - Role of Herbal Medicines in the Management of Brain Injury.
Safdari MR, Shakeri F, Mohammadi A, Bibak B, Alesheikh P, Jamialahmadi T, Sathyapalan T, Sahebkar A. Safdari MR, et al. Adv Exp Med Biol. 2021;1328:287-305. doi: 10.1007/978-3-030-73234-9_19. Adv Exp Med Biol. 2021. PMID: 34981485 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials